Zongertinib Drives High Response in First-Line HER2-Mutant Lung Cancer
The selective HER2 inhibitor achieved a 76% objective response rate and durable progression-free survival in treatment-naive patients.
Plasma p-tau217 Assays Show High Specificity for Alzheimer’s Diagnosis
Three diverse assay technologies demonstrate 100% specificity in differentiating Alzheimer’s from vascular and frontotemporal dementias.
Obesity and Prediabetes Rates Rise Among Northern Great Plains Children
A multi-year screening of American Indian students shows obesity rates exceeding 40% and a doubling of prediabetes prevalence.
Macrophage PRMT9 Limits Myocardial Infarction Damage in Mice
Researchers found that PRMT9 triggers STAT1 degradation to suppress inflammation and reduce infarct size in experimental models.
AI Ensemble Matches Expert Consensus for Ultrasound Pneumothorax Detection
An explainable AI model achieved 100% sensitivity and specificity, reducing false positives compared to clinicians in M-mode imaging.
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
ILCOR Standardizes Reporting for Resuscitation Education Research
A new Utstein style consensus report defines 111 specific metrics to unify how training efficacy is measured across clinical cohorts.
Fecal Transplant Fails to Decolonize Resistant Bacteria in GI Disease
A randomized trial shows single-dose fecal microbiota transplant does not reduce multidrug-resistant organisms or resistance genes.
GNAO1-Related Disorders Follow Non-Degenerative Course Despite Progressive Movement Symptoms
A longitudinal study of 66 patients shows cognitive stability while severe cases face functional burden from worsening movement disorders.
TTVR Eliminates Severe Tricuspid Regurgitation in Real-World Registry
A US registry study of 1,034 patients shows 98% procedural success and significant functional gains with low 30-day mortality.
MTOR Hyperactivation Suppresses Autophagy and Drives Neuroinflammation in Schizophrenia
Restoring cellular waste clearance via mTOR inhibition reduces pro-inflammatory cytokines and glial activation in schizophrenia models.
Chronotherapeutic Protocol Advances Circadian Timing and Extends Adolescent Sleep
A two-week intervention using light-modulating glasses and scheduling increased weeknight sleep by 47 minutes in high school students.