Vascular Comorbidities Double Mortality Risk in Haploidentical Transplants
A machine-learning analysis identifies a vascular penalty and a three-factor tool to optimize donor selection in allogeneic HCT.
Cryo-EM Maps Molecular Shift Producing Thrombin in Coagulation Cascade
Researchers identify a 20-angstrom reorientation required for the final proteolytic cleavage of prothrombin into active thrombin.
Endometrial Cancer Mortality Rises as Management Shifts to Molecular Subtyping
Rising incidence in younger women and stark racial disparities in mortality underscore the need for early biopsy and tailored therapy.
Amoxicillin Equals Amoxicillin-Clavulanate for Acute Sinusitis
A nationwide cohort study shows standard amoxicillin is as effective as amoxicillin-clavulanate but avoids higher risks of C. difficile.
Routine ICU Delirium Screening Misses 72% of Cases in Spanish Speakers
Caregiver-administered assessments can recover nearly half of missed delirium diagnoses when patient-provider language barriers exist.
Serious Games Reduce Geriatric Trauma Undertriage in Nontrauma Centers
A randomized trial of 800 emergency physicians shows digital simulation training improves adherence to triage guidelines for older adults.
Mobile ECMO Truck Matches In-Hospital Survival in Cardiac Arrest
A mobile ECMO truck delivering scene-based resuscitation achieved a 25% neurologically favorable survival rate, matching in-hospital care.
Alteplase Before Thrombectomy Loses Value After 170 Minutes
A 16-country analysis shows bridging therapy for large vessel occlusion is only cost-effective when initiated early after stroke onset.
Ambulance Lights and Sirens Save Only Three Minutes During Patient Transport
A study of 25,902 incidents suggests the modest time savings of emergent transport may not justify the tripled risk of collisions.
Risk-Adapted Therapy Improves Survival in Pediatric Acute Myeloid Leukemia
Refined stratification using measurable residual disease and genetics increased 3-year overall survival to 83.9% in a large cohort.
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.