Polymeric Clips Match Stapler Safety at Lower Cost in Appendectomy
A retrospective study of 692 patients shows polymeric clips are a cost-effective alternative to staplers for appendiceal stump closure.
Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
Danish Registry Data Show Rising ADHD Medication Use and Sex Convergence
Prevalence tripled among girls between 2010 and 2023, though they continue to initiate treatment two years later than boys.
Ubiquinol Slows Motor Decline in Multiple System Atrophy Trial
A Phase 2 trial provides the first placebo-controlled evidence of disease modification by targeting mitochondrial dysfunction in MSA.
Iron Deficiency Drives Dopaminergic Hypersensitivity in Rodent Restless Legs Model
A study in mice links brain iron deficiency to increased GABA release in the striatal-entopeduncular pathway, mimicking opioid withdrawal.
Pediatric Knife Fatalities Linked to Deprivation and Prior Social Service Contact
A five-year review of 145 deaths in England identifies high rates of pre-hospital mortality and significant psychosocial vulnerabilities.
Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
Vision-Enabled GPT Predicts Tube Thoracostomy Need in Spontaneous Pneumothorax
A retrospective study shows a generative model accurately measures apical depth and aligns with emergency department triage decisions.
Pre-Diagnosis FEV1 Decline Predicts Mortality in Lung Transplant Recipients
A 20-year cohort study shows that the rate of lung function loss before CLAD onset identifies patients at high risk for rapid progression.
Valproate Linked to Higher Mortality in Patients With Dementia and Epilepsy
A Swedish registry study finds lamotrigine and levetiracetam associated with better survival than valproate or carbamazepine.
Vascular Comorbidities Double Mortality Risk in Haploidentical Transplants
A machine-learning analysis identifies a vascular penalty and a three-factor tool to optimize donor selection in allogeneic HCT.
Cryo-EM Maps Molecular Shift Producing Thrombin in Coagulation Cascade
Researchers identify a 20-angstrom reorientation required for the final proteolytic cleavage of prothrombin into active thrombin.