Annals of Neurology
Mendelian Randomization Study
Plasma Proteins Predict Multiple Sclerosis Risk and Disease Severity
An integrated genetic-proteomic analysis identifies specific circulating proteins associated with MS risk and progression, offering potential…
British Journal of Sports Medicine
Mendelian Randomization Study
Higher Activity Volumes, Cardiorespiratory Fitness Offer Greater CVD Risk Reduction
A UK Biobank cohort study and Mendelian randomization suggest current physical activity guidelines provide modest protection, with optimal benefits.
Rhinology
Mendelian Randomization Study
Cathepsin S Links to Tissue Remodeling, Severity in Chronic Rhinosinusitis with Nasal Polyps
Integrative multi-omics analysis identifies cathepsin S (CTSS) as a key mediator of tissue remodeling and disease severity in CRSwNP.
Molecular Psychiatry
Mendelian Randomization Study
Cell-Specific Gene Expression Analysis Identifies Schizophrenia Risk Drivers
Researchers mapped 466 causal genes across eight brain cell types, pinpointing MAU2 and PPP1R13B as high-priority therapeutic targets.
Nature Aging
Mendelian Randomization Study
Beta-1 Blockers May Reduce Vascular Dementia Risk in Genetic Analysis
A Mendelian randomization study suggests beta-1 adrenergic antagonism protects white matter, while ACE inhibition may increase risk.