Lumateperone Leads Efficacy While Aripiprazole Shows Best Acceptability in Depression
A meta-analysis of 10,962 patients quantifies the trade-offs between symptom reduction and treatment adherence for adjunctive antipsychotics.
Iron Overload Linked to High Rates of Hypogonadism and Infertility
A systematic review of over 3,000 patients finds nearly half of men and women face severe reproductive impairment from iron toxicity.
Intravenous Ketamine Reduces Suicidal Ideation and Depression for One Month
A meta-analysis of 26 trials shows rapid symptom relief within four hours and sustained antisuicidal effects following intravenous infusion.
Low Geriatric Nutritional Risk Index Increases Postoperative Delirium Risk
A meta-analysis of 12,332 patients finds that low preoperative nutritional scores correlate with a 62% higher risk of delirium.
Noncardiac Death Risk Limits Cardiovascular Prognosis in Type 2 Infarction
A meta-analysis of 120,734 patients shows that high noncardiovascular mortality competes with ischemic risk in Type 2 myocardial injury.
Water Access and Vaccination Linked to Lower Pediatric HIV Mortality
Meta-regression of 67 cohorts identifies water access, pneumococcal vaccination, and maternal education as key predictors of survival.
Pure Autonomic Failure Carries 5% Annual Risk of Central Phenoconversion
A meta-analysis identifies hyposmia and sleep disturbances as key predictors of progression to Parkinson disease or multiple system atrophy.
Heartbeat Evoked Potential Lacks Consistency for Clinical Use
A meta-analysis finds that methodological variability prevents using this neural marker of interoception as a reliable diagnostic tool.
Survival Improves for Leukemia Patients Requiring Mechanical Ventilation in the ICU
An individual participant data meta-analysis of 2003 patients shows declining mortality for ventilated adults with acute leukemia.
ME/CFS Linked to Reduced Bioactive Cortisol and Heightened Feedback Sensitivity
A meta-analysis of 46 studies confirms a neuroendocrine signature of low cortisol and HPA-axis hyporeactivity in chronic fatigue patients.
Bitemporal ECT and rTMS Plus SSRIs Reduce Suicidal Ideation
A network meta-analysis of 58 trials finds nonconvulsive brain stimulation alone is ineffective for suicidal ideation without medication.
Maternal Depressive Symptoms Nearly Double Preeclampsia Risk
A meta-analysis of over 44,000 pregnancies shows early depressive symptoms significantly elevate the risk of hypertensive complications.