Astrocytic Hemichannel Overactivity Drives Prefrontal Circuit Deficits in Schizophrenia Models
Elevated connexin 43 in the prefrontal cortex triggers excessive glutamate release, offering a potential non-neuronal therapeutic target.
Blood MicroRNA Signatures Correlate With Hippocampal Volume and Atrophy Rates
Specific microRNA expression patterns in whole blood may serve as early markers for structural brain changes and neurodegenerative risk.
ME/CFS Linked to Reduced Bioactive Cortisol and Heightened Feedback Sensitivity
A meta-analysis of 46 studies confirms a neuroendocrine signature of low cortisol and HPA-axis hyporeactivity in chronic fatigue patients.
IL-15 Receptor Deficiency Drives Depressive Behaviors via Microglial Synapse Pruning in Mice
Loss of IL-15RA signaling triggers prefrontal cortex synapse loss through the CX3CL1 pathway, offering a potential target for depression.
Cell-Specific Genetic Mapping Links Neuronal and Immune Pathways to Neuropsychiatric Risk
Analysis of six major disorders identifies 345 risk genes, highlighting the role of microglia and astrocytes in disease pathogenesis.
French Cohort Study Maps Perinatal Risks for Neurodevelopmental Disorders
A study of 7.4 million children identifies shared and distinct risk factors for ADHD, autism, and intellectual disability.
Prenatal Sterol-Inhibiting Drugs Linked to Increased Autism Risk
A study of 6 million births found that common medications disrupting cholesterol synthesis increase autism risk in a dose-dependent manner.
Distinct Cortical Thickness Patterns Define Positive and Negative Schizotypy
MRI analysis of 2730 healthy adults links subclinical traits to specific neurotransmitter systems and neurodevelopmental disorders.
Ceruloplasmin Deficiency Linked to Fusiform Gyrus Pathology in Autism Subtype
Low ceruloplasmin levels drive lipid and myelin imbalances in children with autism and atypical visual processing.
GLP-1 Agonists Show No Increased Suicide Risk in Large Cohort
A nationwide study finds GLP-1 receptor agonists carry no higher risk of suicide attempts than other common antidiabetic medications.
Autism Shares Genetic Risk Loci With Diabetes and Heart Disease
Large-scale genomic analysis identifies 100 shared loci linking autism spectrum disorder to metabolic and cardiovascular phenotypes.
Cross-Ancestry Analysis Identifies Shared Genetic Risk for Major Psychiatric Disorders
Researchers identified 403 genetic loci and specific cellular pathways common to schizophrenia, bipolar disorder, and depression.