Retinal Imaging AI Screens for Six Systemic Metabolic and Endocrine Diseases
A multitask framework identifies diabetes, hypertension, and osteoporosis from fundus photos, showing high negative predictive value in primary care.
All of Us Program Links 14 Years of Wearable Data to Clinical Records
A massive dataset connects Fitbit metrics from 59,000 participants to genomics and electronic health records for longitudinal research.
Targeted sFlt-1 Apheresis Safely Extends Pregnancy in Very Preterm Preeclampsia
A pilot trial shows selective removal of sFlt-1 reduces maternal blood pressure and delays delivery by a median of 10 days.
Host Antibodies and Bacterial Heteroresistance Drive Phage Therapy Failure
Pre-existing anti-prophage antibodies and bacterial subpopulations with reduced susceptibility may neutralize therapeutic bacteriophages.
Targeted Agents Fail to Extend Survival in Pediatric Brainstem Glioma
The BIOMEDE trial finds no survival benefit for erlotinib, dasatinib, or everolimus, but identifies TP53 as a key prognostic marker.
Improved House Design Reduces Malaria and Respiratory Infections in Children
A cluster-randomized trial in rural Africa shows that Star Homes lower malaria incidence by 44% and improve linear growth in children.
Picloram Exposure Increases Early-Onset Colorectal Cancer Risk in Epigenetic Analysis
Methylation risk scores identify the herbicide picloram as a significant driver of colorectal cancer in patients under age 50.
Seven-Day Low-Plastic Intervention Lowers Urinary Phthalates and Bisphenol A
A randomized trial shows that minimizing plastic contact in food and personal care reduces endocrine disruptors linked to metabolic risk.
Cibisatamab and FAP-4-1BBL Show Activity in Refractory Colorectal Cancer
A phase 1b trial finds that combining a CEA-targeted bispecific antibody with localized 4-1BB co-stimulation induces objective responses.
Cilta-cel Induces Universal MRD Negativity in High-Risk Smoldering Multiple Myeloma
A phase 2 trial shows 100% of patients achieved deep, sustained responses without prior induction therapy or disease progression.
Gut Microbiome Signature Identifies Premanifest Parkinson’s Disease Risk
Metagenomic analysis reveals a microbial state in GBA1 carriers that correlates with prodromal symptoms and disease progression.