Muscle Cramp Impact Index Validated for Multidimensional Symptom Assessment
A new 14-item tool measures how muscle cramps interfere with sleep and daily life across neuromuscular, renal, and hepatic conditions.
Remote Multicomponent Rehabilitation Does Not Improve Quality of Life for ICU Survivors
A randomized trial found a 6-week remote rehabilitation program did not significantly enhance health-related quality of life at 8 weeks.
Acquired Anosmia Affects Quality of Life More Than Congenital Anosmia
A study of 59 patients reveals how the origin and duration of anosmia influence perceived impairment and coping.
Spatial Proteomics Identifies Plaque-Associated Microglia in Alzheimer's Brains
A new imaging technology reveals a specific microglial subpopulation linked to dense amyloid-beta plaques in human Alzheimer's disease.
MSC-Exos Restore Hippocampal Neuron Morphology After Stress via Wnt5a Pathway
Mesenchymal stem cell-derived exosomes mitigate stress-induced morphological deficits in hippocampal neurons through a specific signaling pathway.
Periventricular Lesions Drive Cognitive Decline by Disrupting Cholinergic Pathways in Parkinson's
White matter injury triggers cortical terminal loss and retrograde atrophy, identifying a structural biomarker for cognitive risk.
PET Imaging Tracks Metabolic Decline Across ALS Clinical Stages
A large cohort study links King's staging to progressive loss of brain connectivity and transient cerebellar recruitment in ALS.
Pre-SRS PD-1 Inhibitor Use Linked to Increased Neurological Deficits, Mortality
A multi-institutional study suggests administering PD-1 inhibitors before stereotactic radiosurgery in glioma patients may worsen outcomes.
Younger Brain Age Buffers Cognitive Impact of Tau Pathology
Structural brain integrity, but not education level, modifies the link between p-tau217 and cognitive performance in older adults.
4-Hydroxybenzoic Acid Restores Endogenous Coenzyme Q10 in COQ2-Deficient Patient
A first-in-human trial shows 4-HBA bypasses biosynthetic blocks to improve neurological and renal outcomes in primary CoQ10 deficiency.
Semantic-Metacognitive Therapy Improves Naming in Semantic Variant PPA
A single-case experimental study shows specific speech therapy can improve naming performance in individuals with semantic variant primary.
POD1 Prolactin Levels Predict Long-Term Outcomes After Prolactinoma Resection
Postoperative day 1 prolactin levels help stratify risk for hyperprolactinemia rebound and recurrence, especially with prior dopamine agonist use.