Nasal Septal Perforation Impairs Olfactory and Trigeminal Function
A cross-sectional study links larger perforation areas and higher BMI to worse olfactory identification in patients with NSP.
Individual LPFC Maps Reveal Fine-Grained, Interdigitated Networks
Precision fMRI in 10 individuals shows the lateral prefrontal cortex has a more fragmented and functionally distinct organization than group.
Melittin Mitigates Doxorubicin-Induced Neurotoxicity in Murine Models
A study in mice suggests melittin, a bee venom component, reduces doxorubicin's neurotoxic effects by targeting inflammation and oxidative stress.
TSPO Deletion Reduces Cortical Spreading Depolarization in Mice
A new study in mice suggests that modulating translocator protein 18 kDa may influence CSD generation and associated neurovascular and inflammatory re
Low-Dose IL-2 Fails to Expand Tregs After Alemtuzumab in RRMS
A mechanistic study reveals that low-dose interleukin-2 alone does not boost regulatory T cells in alemtuzumab-treated multiple sclerosis patients.
Vertebrobasilar and Middle Cerebral Aneurysms Carry Highest Case Fatality Rates
A population-based study of 13,470 cases shows that aneurysm location significantly influences sudden death and 30-day mortality risks.
Validating Generative AI Therapeutics: A Proposed Framework for Clinical Integration
A new framework outlines a multi-stage validation process to ensure the safety and efficacy of generative AI agents in mental health care.
Cerebellar iTBS Improves Post-Stroke Cognition via Dentate Nucleus-Ventromedial Thalamus Pathway
A mouse model study identifies the specific neural circuit mediating the cognitive benefits of intermittent theta-burst stimulation after stroke.
Fine Particulate Matter Increases Risk of Recurrent Stroke and Death
A national cohort study finds that PM2.5 exposure nearly triples the risk of stroke recurrence and secondary cardiovascular events.
Chronic Pain Mechanisms Show Distinct Cortical Connectivity Patterns
A study using TMS-EEG identifies neurophysiological differences across nociceptive, neuropathic, and nociplastic pain phenotypes.
Amitriptyline Not Superior to Placebo for Leprosy-Related Neuropathic Pain
A randomized controlled trial found amitriptyline did not offer additional analgesia as add-on therapy for neuropathic pain in leprosy.
TMEM106B Variant Delays FTD Onset in GRN Mutation Carriers
A specific genetic variant significantly reduces FTD onset risk and extends median onset age by 14 years in GRN mutation carriers.