Brain Networks Modulate Parkinson's Tremor Amplitude
A large-scale fMRI study identifies distinct brain networks that either produce or actively suppress Parkinson's disease tremor.
Consensus Checklist and Passing Standard for Brain Death Competency
A Delphi and Angoff process established a 98-item checklist and an 89% minimum passing score for BD/DNC determination.
Delayed Awakening After Cardiac Arrest: Prognostic Implications and Recovery Potential
A scoping review highlights variable definitions and the potential for good neurological recovery despite delayed awakening after OHCA.
Foamy Microglia and Lipid Metabolism Link to Multiple Sclerosis Lesion Expansion
A distinct microglial subtype and altered lipid pathways drive lesion progression in secondary progressive MS, suggesting new therapeutic avenues.
Red Blood Cells Contribute Alpha-Synuclein to Parkinson's Brain Pathology
A new study in human tissues and mouse models identifies erythrocytes as a peripheral source of alpha-synuclein, influencing central nervous system.
Idarucizumab Reversal Before Thrombolysis in AIS Patients Shows Comparable Safety
Real-world data suggest intravenous thrombolysis after dabigatran reversal is safe and effective as in non-anticoagulated patients.
Ependymal Cilia Mechanics Control Adult Neural Stem Cell Quiescence
A new study identifies how mechanical forces from ependymal cell cilia regulate neural stem cell activity through specific ion channels.
Multimodal Biomarkers Enhance Parkinsonian Syndrome Diagnosis
Combining dermal alpha-synuclein, 4-repeat tau SAAs, and serum neurofilament light chain improves diagnostic precision for neurodegenerative.
EPAC2 Antagonism Restores Cortical Function, Behavior in Fragile X Mouse Model
Targeting EPAC2 reverses molecular and functional deficits in a preclinical model of Fragile X Syndrome, suggesting a therapeutic avenue.
Postpartum Period Linked to Higher Risk of Myasthenia Gravis Exacerbations
A population-based cohort study clarifies the fluctuating risk of myasthenia gravis exacerbations during and after pregnancy.
Micropipette-Guided Administration Delivers Analgesics to Mouse Brains
A less invasive method for administering carprofen and buprenorphine in mice achieves therapeutic brain levels, particularly for buprenorphine.
Widespread Cortical Alterations in Adolescent Early-Onset Psychosis
A large-scale mega-analysis reveals extensive structural brain differences in adolescents with early-onset psychosis compared to controls.