Plasma GFAP and NfL Predict Long-Term Mortality in Older Adults
Elevated baseline levels of GFAP and NfL strongly correlate with future risk of all-cause, dementia, and cardiovascular death.
Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.
Inhibiting USP22 Halts Periodontitis-Linked Brain Inflammation in Mice
Knocking down the enzyme USP22 in mice prevents the periodontal pathogen P. gingivalis from degrading blood-brain barrier tight junctions.
Women Face Worse Functional Recovery After Intensive Care EEG
Despite similar acute management and mortality, critically ill women are half as likely as men to achieve favorable long-term recovery.
Baseline Breathing Patterns Predict Post-Seizure Hypoxemia Severity
Measuring respiratory variability between seizures may help identify epilepsy patients at highest risk for severe oxygen desaturation.
Brain Imaging Maps How Deep Brain Stimulation Alters Parkinson's Circuits
Extensive functional MRI data from 14 patients reveals that cortical connectivity patterns can predict clinical outcomes of stimulation.
Zorevunersen Cuts Convulsive Seizures in Children With Dravet Syndrome
The investigational antisense therapy reduced convulsive-seizure frequency by up to 90.91% and improved adaptive behavior over 36 months.
ADHD Linked to Attenuated Rightward Structural Asymmetry in Children
MRI data reveal that reduced right-hemisphere dominance in frontal and striatal regions correlates with impaired attention and timing.
Sleep Under 6.7 Hours Linked to Depression in Opioid Users
A U-shaped dose-response curve reveals that insufficient sleep increases depression risk by 60% among adults taking prescription opioids.
Digital Dyadic Interventions Improve Cognition and Reduce Caregiver Burden
A review of 38 studies finds digital tools like mobile apps and remote platforms enhance patient cognition and ease caregiver burden.
Real-World CBT Improves Distress but Not Pain in Functional Neurological Disorder
Routine clinical data from 234 adults shows cognitive behavioral therapy significantly reduces psychological distress but not physical pain.
Social Skills Training Modulates Local Connectivity in the Autistic Social Brain
A 14-week intervention reduces regional homogeneity in the medial frontal gyrus, correlating with improved social responsiveness scores.