TFPI Essential for Embryonic Brain Vessel Development, Protein C Mitigates Defects
A preclinical study in mice reveals tissue factor pathway inhibitor's critical role in preventing cerebrovascular malformations and lethality.
Evolutionary Adaptation Reveals Neuronal Pathway for Myelination and Repair
A Retsat variant from high-altitude species uncovers a neuron-to-glia signaling mechanism that promotes central nervous system myelin formation…
Autoimmune Encephalitis Subtypes Identified in Rapidly Progressive Dementia
A multicenter study clarifies the prevalence and clinical presentations of specific autoimmune encephalitis subtypes in patients with rapidly progress
Specific Genetic Elements Control Blood-Brain Barrier Endothelial Cell Function
Researchers identify a key DNA segment and transcription factors that regulate the unique gene expression of CNS vascular endothelial cells.
Linear Distance Modulates Brain's Gender Agreement Processing
A study in Norwegian speakers clarifies how word separation impacts neural responses to grammatical gender violations, using Event-Related Potentials.
ATF2 Phosphorylation Drives Neuronal Apoptosis in Neurodegenerative Disease Models
A genome-wide screen identifies a specific molecular cascade involving ATF2 phosphorylation as a core driver of neuronal cell death.
Plantar Agraphesthesia Signals Lower Limb Cortical Sensory Loss in Corticobasal Syndrome
A case report details how plantar agraphesthesia can indicate cortical sensory deficits in the lower limb, even without hand involvement.
Successful HSCT Slows Brain Volume Loss in Adults With Sickle Cell Disease
A cohort study indicates that successful hematopoietic stem cell transplant is associated with preserved brain volume in adults with SCD.
VTA-mPFC Dopamine Circuit Drives Stress-Induced Sleep Fragmentation in Mice
A new study in mice identifies specific dopaminergic neuron hyperexcitability as a key mechanism behind chronic stress-related sleep disruption.
Plasma p-tau217, Cognition, APOE4 Predict Alzheimer's Dementia Risk in SCD
A multimodal approach combining readily available biomarkers accurately identifies individuals with subjective cognitive decline at high risk for Alzh
CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
MMAE for cSDH: Resolution Trajectories and Functional Outcomes Quantified
A large multicenter study details the temporal patterns of hematoma reduction and functional recovery after middle meningeal artery embolization.