French NOMADMUS Cohort Details AQP4+NMOSD, MOGAD Trends
A nationwide registry in France provides real-world data on diagnostic and therapeutic shifts, and disease activity in AQP4+NMOSD and MOGAD.
CT-Detected White Matter Disease Signals Higher Stroke/Dementia Risk Than MRI-Only Findings
A large cohort study reveals distinct prognostic implications for covert cerebrovascular disease based on imaging modality.
Smoking Cessation Reduces Dementia Risk, But Weight Gain May Attenuate Benefit
A large prospective cohort study indicates quitting smoking lowers long-term dementia risk, though substantial post-cessation weight gain may…
ERV Reactivation Drives C4b-Mediated Synaptic Pruning in Autism Models
In mouse models, endogenous retrovirus reactivation leads to C4b upregulation and excessive microglial pruning, contributing to autistic-like…
Homozygous LGI1 Variant Linked to Severe Developmental and Epileptic Encephalopathy
A case report details a homozygous LGI1 gene variant causing drug-resistant epilepsy and profound developmental delay, contrasting with typical.
Blood Test Monitors Brain Gene Expression in Nonhuman Primates
A new method uses engineered reporters to noninvasively track transgene activity in primate brains via a simple blood draw.
T-Cell Lymphoma Neuropathy Differs From B-Cell Counterpart, Often Neurolymphomatosis
A multicenter study details the distinct clinical and pathological features of peripheral neuropathies in T-cell lymphoproliferative disorders.
New Imaging Reveals Hippocampal Dendrite Signaling Dynamics In Vivo
A novel 3D motion-corrected imaging platform allows direct observation of electrical and calcium activity in live neuronal dendrites.
TTP: EEG Delta Activity Correlates With Transient Aphasia, Resolves With Treatment
A case report details how left temporal lateralized rhythmic delta activity (LRDA) on EEG tracked fluctuating aphasia in TTP, resolving with targeted
AL Amyloidosis Prognostic Models Lag Behind Treatment Advances
Current risk stratification tools for AL amyloidosis do not reflect improved patient outcomes with modern daratumumab-based regimens.
Noradrenaline-Amygdala Circuit Modifies Aversive Memories During Recall
A new study in rats identifies a specific brainstem-amygdala pathway and molecular mechanism governing aversive memory reconsolidation.
Neurobehavioral Profile of Young Steroid-Naive Boys With Duchenne Muscular Dystrophy
A multinational study characterizes baseline social, emotional, and learning challenges in young boys with Duchenne muscular dystrophy.