Prenatal Distress Linked to Altered Cortical Folding and Child Behavior
Second-trimester maternal anxiety correlates with reduced gyrification and increased social withdrawal in children at age eight.
Distributed HABIT-ILE Dosing Matches Massed Therapy for Bilateral Cerebral Palsy
Spreading 90 hours of intensive bimanual and lower extremity therapy over 15 weeks yields functional gains equivalent to 3-week programs.
Antipsychotics and Antiemetics Drive Pediatric Drug-Induced Dystonia
A study of 79 children finds most reactions occur within 72 hours of exposure and respond rapidly to parenteral biperiden.
Early Probiotics Reduce Mortality in Extremely Preterm Infants
A Norwegian registry study of 1,596 neonates finds early probiotic use lowers death risk and may reduce surgical necrotizing enterocolitis.
Mim8 Prophylaxis Reduces Bleeding in Hemophilia A with or without Inhibitors
Phase 3 data show weekly or monthly subcutaneous Mim8 significantly lowers bleeding rates compared to on-demand and prior factor therapy.
Clinical Models Improve Pediatric Referral Accuracy in Southeast Asia
New triage tools utilizing pulse oximetry and sTREM1 show higher sensitivity for severe febrile illness than current WHO standards.
Trauma Center Type Does Not Predict Outcomes in Pediatric Liver Injury
A national TQIP analysis finds that facility verification status does not independently influence intervention rates or mortality.
Visual Cortex Pathways Form Adult-Like Architecture Before Birth
MRI data from 584 neonates show that dorsal and ventral streams develop at different rates during the third trimester.
Digital and Primary Care Intervention Reduces Adolescent Depressive Symptoms in Slums
A randomized trial in India shows a multimedia campaign and digital tools improve mental health literacy and lower PHQ-9 scores.
Nasoalveolar Molding Limits Early Lip Revisions in Cleft Patients Through Maturity
A 20-year follow-up shows only 3.7% of patients required lip revision before reaching skeletal maturity after nasoalveolar molding.
Lung Ultrasound Reaches 94% Sensitivity for Pediatric Pneumonia Diagnosis
Meta-analyses indicate point-of-care ultrasound offers up to 96% specificity while eliminating radiation exposure in children.
Intravenous Tocilizumab Stabilizes Severe Pediatric Neuroinflammation Within 72 Hours
A retrospective study shows rapid clinical improvement and intracranial pressure reduction in children with refractory CNS inflammation.