Pain
Cohort Study
Chronic Pain Mechanisms Show Distinct Cortical Connectivity Patterns
A study using TMS-EEG identifies neurophysiological differences across nociceptive, neuropathic, and nociplastic pain phenotypes.
Pain
Randomized Controlled Trial
Amitriptyline Not Superior to Placebo for Leprosy-Related Neuropathic Pain
A randomized controlled trial found amitriptyline did not offer additional analgesia as add-on therapy for neuropathic pain in leprosy.
Pain
Cohort Study
Psychological Factors Predict High-Impact Chronic Pain in Sickle Cell Disease
A prospective study of 90 patients shows that pain catastrophizing and low self-efficacy correlate with sustained functional impairment.
Pain
Cross-Sectional Study
Sleep and Psychological Symptoms Moderate Physical Activity Benefits in Pediatric Pain
A study of 212,105 adolescents shows that exercise effects on back pain and stomachache depend on comorbid sleep and mood profiles.
Pain
Animal Study
Endothelial Nitric Oxide and Nitrosative Stress Drive Potassium Channel Migraine Pain in Mice
Mouse study finds that KATP channel-induced hypersensitivity requires eNOS and peroxynitrite rather than traditional cGMP signaling.