The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
24 stories-
SCCM and ESICM launch 2026 guideline for Sepsis and Septic Shock Management
The updated Surviving Sepsis Campaign guidelines emphasize earlier, more precise interventions, including new screening tool recommendations.
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CANMAT and ICOCS launch 2025 international guideline for Obsessive-Compulsive Disorder
New joint guidelines establish a clear, tiered algorithm for OCD management, solidifying first-line options and defining evidence-based augmentation.
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AHA and ACC launch 2026 guideline for Acute Pulmonary Embolism in Adults
A new clinical categorization system for acute PE refines risk stratification, enabling more precise management and expanding outpatient treatment.
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Autism Subtypes Linked to Distinct Brain Connectivity and Biological Pathways
A cross-species neuroimaging study identifies two replicable autism subtypes with specific functional connectivity patterns and biological underpinnin
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Simvastatin Rescues Cognitive Impairment in Alzheimer's Model via Epigenetic and Synaptic Pathways
A preclinical study in mice identifies specific molecular mechanisms by which simvastatin may improve cognitive function in Alzheimer's disease.
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Military Blood Supply Insufficient for Large-Scale Combat Operations
Simulation reveals current Forward Resuscitative Surgical Detachment blood strategies, even with walking blood banks, fail rapidly under high casualty
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Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
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Somatic Symptoms, Sensory Dysregulation Are Core to PTSD Presentation
Current PTSD treatments often fall short because they overlook the central role of physical sensations and sensory processing.
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Cameroon Football Reveals Gaps in Cardiac Screening, Emergency Preparedness
A cross-sectional study highlights critical deficiencies in cardiovascular screening and sudden cardiac arrest response among football teams in Camero
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ED Nudge Strategy Increases Naltrexone Prescribing for Alcohol Misuse
A multicomponent emergency department protocol significantly raised naltrexone initiation for patients with alcohol-related diagnoses.
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Refining Lower Limb TMS: Identifying MEPs in Resting Ipsilateral Muscles
This study quantifies motor evoked potentials in the non-target resting leg, offering methodological clarity for transcranial magnetic stimulation.
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IBD Inflammation Augments CHIP Risk, APE1/Ref-1 Identified as Therapeutic Target
A new study links inflammatory bowel disease to increased clonal hematopoiesis of indeterminate potential, identifying a specific molecular pathway.
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Demographics Influence Etiology in 2,052 Patients With Late-Onset Seizures
A multicenter study finds that while stroke remains common, neurodegeneration and unexplained causes dominate the geriatric epilepsy profile.
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Selective HDAC6 Inhibition Improves Motor Function in Preclinical ALS Models
A CNS-penetrant small molecule restores protein clearance and axonal transport, reducing neurofilament levels and TDP-43 pathology.
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Intravenous Magnesium Sulfate Reduces Rescue Analgesia for Acute Headache
A randomized trial finds adjunctive magnesium sulfate increases treatment success and patient satisfaction, despite pain reduction not meeting clinica
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Multimodal AI System Matches Clinicians in Simulated Telehealth Diagnostics
A new AI system, multimodal AMIE, integrates diverse data types to achieve high diagnostic accuracy and conversational quality in simulated telehealth
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ALS Subtypes Show Distinct Immune Remodeling, Linking Blood Changes to Spinal Cord Damage
A new study details specific immune cell dynamics and molecular programs in ALS, revealing distinct patterns across disease subtypes.
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Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
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SHANK3 Haploinsufficiency in Macaques Reveals Diverse Behavioral, Cognitive Phenotypes
A new macaque model of SHANK3 haploinsufficiency provides insights into Phelan-McDermid syndrome and potential biomarkers.
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SSPOP Mutations Linked to Pediatric Epilepsy and Developmental Disorders
Researchers identify pathogenic variants in a supposed pseudogene, expanding the diagnostic landscape for unexplained neurodevelopmental delay.
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Long-Duration Levodopa Response Distinguishes Parkinson's, Predicts Outcomes
A study details how sustained levodopa motor improvement helps differentiate parkinsonian syndromes and offers prognostic insights for PD.
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Gender-Affirming Mastectomy Linked to Sustained Satisfaction, Quality of Life
A cross-sectional study finds high patient-reported chest satisfaction and psychological well-being years after gender-affirming mastectomy.
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Alantolactone and Temozolomide Combination Targets Glioblastoma Stemness, Lipid Metabolism
Preclinical findings suggest alantolactone combined with temozolomide may overcome glioblastoma resistance by modulating the Hippo pathway.
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Digital and Mixed Interventions Support Physical Activity After Exercise Therapy
An umbrella review suggests digital and mixed delivery methods help patients with chronic conditions maintain physical activity and quality of life.