Anesthesia Trials Lack Precise Definitions for Perioperative Disruptions
A review of 139 trials finds 60% fail to report how they handle events like surgery cancellations or treatment switching.
Preoperative Beta Connectivity Predicts Delirium Risk in Older Surgical Patients
A multicenter study finds reduced brain network communication at baseline identifies vulnerability, though EEG patterns recover by 3 months.
Hypothalamic Astrocytes Drive Dexmedetomidine Sedation via Calcium Signaling in Mice
Researchers identified a specific astrocytic pathway that modulates inhibitory GABA currents to facilitate pharmacological sedation.
Subanesthetic Ketamine Improves Depressive Symptoms in Critically Ill Adults
A retrospective study finds three days of low-dose ketamine reduces sadness in ICU patients with minimal hemodynamic impact.
Inhaled Methoxyflurane Avoids IV Sedation in Half of Prehospital Fractures
Inhaled methoxyflurane successfully facilitated prehospital limb reduction in 54% of patients without requiring intravenous sedation.
Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.
Continuous Rocuronium Yields Modest Intracranial Pressure Reductions
A retrospective analysis reveals that continuous neuromuscular blockade lowers intracranial pressure by only 1 to 2 mm Hg in severe cases.
Limiting ICU Wrist Restraints Fails to Increase Delirium-Free Days
A restrictive wrist-strap protocol in mechanically ventilated adults did not improve delirium-free days or increase self-extubation risk.