Non-Intubated ECMO Failure Linked to Seven-Fold Increase in 90-Day Mortality
An international cohort study finds that while avoiding mechanical ventilation during ECMO is feasible, failure carries high mortality risks.
Microglial Activation Disrupts Hippocampal Memory Consolidation in Aged Mice After Surgery
Surgical stress triggers neuroinflammation that inhibits CA3 to CA1 signaling, reducing sharp-wave ripples essential for memory.
Automated Software Matches Clinician Accuracy in Peri-operative Echocardiography
A multicenter study shows high agreement between AI-driven analysis and expert measurements for ejection fraction and valvular disease.
Automated Model Predicts Surgical Complications Across 14 Health Systems
A multicenter analysis of 508,097 encounters shows high accuracy in predicting ICU admission, kidney injury, and in-hospital mortality.
Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
Airway Ultrasound Training Lacks Global Standardization Despite Clinical Utility
A scoping review of 11 training programs reveals inconsistent curricula and significant barriers to formal anesthesia education.
Remimazolam Impairs Thalamic Auditory Gating During Recovery in Mouse Models
Dysfunction in the thalamic reticular nucleus leads to sensory hypersensitivity and rebound neuronal enhancement following anesthesia.
Hospital and Surgeon Culture Drive Extended-Release Opioid Use After Arthroplasty
A study of 229,995 joint replacements shows institutional patterns, not patient factors, primarily dictate postoperative long-acting opioid dispensing
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
Institutional Habits Drive Extended-Release Opioid Use After Joint Replacement
A study of 229,995 arthroplasty patients finds that hospital and surgeon factors, not patient risk, dictate postoperative opioid dispensing.
Anesthesia Trials Lack Precise Definitions for Perioperative Disruptions
A review of 139 trials finds 60% fail to report how they handle events like surgery cancellations or treatment switching.