Annals of Neurology
Cohort Study
Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
Annals of Neurology
Cohort Study
Plasma p-Tau217 Matches PET for Modeling Alzheimer's Timelines
Plasma p-tau217 accurately estimates the onset of amyloid and tau pathology, offering an accessible alternative to expensive PET scans.
Annals of Neurology
Case Series
CD4+ T-Cells Infiltrate Hypocretin Region in Narcolepsy Type 1
Postmortem analysis shows an 11-fold increase in CD4+ T-cells specifically within the hypothalamus, supporting an autoimmune etiology.
Annals of Neurology
Diagnostic Accuracy Study
Algorithm Predicts Parkinsonism Pathology From Clinical Symptoms
A machine learning tool trained on brain bank data uses 23 clinical parameters to accurately predict post-mortem pathology in parkinsonism.