Cutamesine Mitigates Hippocampal Damage in In Vitro Ischemia Models
A sigma-1 receptor agonist reduced neuronal cell death and cellular stress markers in rat hippocampal slices exposed to oxygen-glucose deprivation.
Refining Lower Limb TMS: Identifying MEPs in Resting Ipsilateral Muscles
This study quantifies motor evoked potentials in the non-target resting leg, offering methodological clarity for transcranial magnetic stimulation.
Alantolactone and Temozolomide Combination Targets Glioblastoma Stemness, Lipid Metabolism
Preclinical findings suggest alantolactone combined with temozolomide may overcome glioblastoma resistance by modulating the Hippo pathway.
Acupuncture and Herbal Formula Improve Visual Acuity in Optic Atrophy
Combining acupuncture with Jieyu Huoxue Formula reduces blood viscosity and increases peak systolic velocity to protect the optic nerve.
Galectin-3 Inhibition Prevents Excitatory Synapse Loss in Murine Neuroinflammation Models
Targeting microglial Galectin-3 preserves hippocampal gamma power and cognitive function by stopping the selective engulfment of synapses.
Aging Rats Show Inverted Hypothalamic Response to Ghrelin Signaling
Age-related increases in ghrelin receptor expression coincide with a shift from neuronal activation to inhibition in the dorsomedial nucleus.
Cajanine Reduces Anxiety and Fear Extinction Deficits in Female Mice
The compound modulates the ERβ/NF-κB pathway to alleviate neuroinflammation and behavioral symptoms in a sex-specific manner.
MRI Tracks Hippocampal Damage and Recovery in Rat Epilepsy Model
A longitudinal study in rats reveals acute hippocampal volume loss after status epilepticus, followed by partial recovery over 30 days.
Dopamine Blockade Attenuates Morphine Analgesia in Rat Hippocampus
Blocking D1 dopamine receptors in the dentate gyrus significantly reduces the pain-relieving effects of morphine in an animal model.
Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
Inhibiting RhoA in Rat Prefrontal Cortex Reduces Morphine Dependence
Blocking the RhoA pathway in rats reduces opioid-induced neuroplasticity and limits glutamate spillover, offering a specific addiction target.