Dupilumab Reduces COPD Hospitalizations, ED Visits, and Corticosteroid Use
A pooled analysis of two phase 3 trials shows dupilumab significantly lowers healthcare utilization and corticosteroid burden in COPD patients.
Selective Early PDA Pharmacotherapy Feasible in Extremely Preterm Infants
A pilot randomized trial demonstrates the feasibility of a targeted medical approach for patent ductus arteriosus in infants under 26 weeks'.
Non-Ischemic Dilated Cardiomyopathy: Higher Prevalence, Complex Genetics
Updated estimates suggest non-ischemic dilated cardiomyopathy affects 1 in 220, driven by diverse genetic and environmental factors.
New Tool Assesses Integrative Oncology Competencies in Trainees
A validated questionnaire helps evaluate baseline clinical skills in integrative oncology among healthcare provider trainees, supporting targeted.
Remote Multicomponent Rehabilitation Does Not Improve Quality of Life for ICU Survivors
A randomized trial found a 6-week remote rehabilitation program did not significantly enhance health-related quality of life at 8 weeks.
Acquired Anosmia Affects Quality of Life More Than Congenital Anosmia
A study of 59 patients reveals how the origin and duration of anosmia influence perceived impairment and coping.
ICU Readmission Increases 60-Day Mortality Regardless of Frailty Status
A large registry study finds frail, readmitted patients face the highest mortality, but frailty does not alter readmission's incremental risk.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Spatial Proteomics Identifies Plaque-Associated Microglia in Alzheimer's Brains
A new imaging technology reveals a specific microglial subpopulation linked to dense amyloid-beta plaques in human Alzheimer's disease.
AD109 Reduces Apnea-Hypopnea Index in PAP-Intolerant OSA Patients
An oral combination of aroxybutynin and atomoxetine significantly improved objective respiratory metrics over 26 weeks.
Stag2 Deficiency Reprograms GATA1 Binding, Driving Dyserythropoiesis in Myelodysplastic Syndromes
Loss of Stag2 alters chromatin accessibility, redirecting GATA1's transcriptional activity from erythroid to megakaryocyte pathways.
Genetic Maps Reveal Psychiatric Disorder Clusters, Clinical Feature Links
A Swedish register study maps genetic risk for 12 disorders, showing how liabilities vary with sex, onset age, and recurrence.