Fine Particulate Matter Increases Risk of Recurrent Stroke and Death
A national cohort study finds that PM2.5 exposure nearly triples the risk of stroke recurrence and secondary cardiovascular events.
Cathepsin S Links to Tissue Remodeling, Severity in Chronic Rhinosinusitis with Nasal Polyps
Integrative multi-omics analysis identifies cathepsin S (CTSS) as a key mediator of tissue remodeling and disease severity in CRSwNP.
4% Tetrasodium EDTA Lock Reduces CVAD Complications in ICU Adults
A multicenter, cluster-randomized trial shows 4% t-EDTA locking fluid decreases a composite of CVAD-associated events, primarily catheter occlusions.
VSED with Hospice: Clinical Course, Symptom Management, and Patient Demographics
A case series details the clinical trajectory, symptom burden, and care needs of patients choosing voluntarily stopping eating and drinking.
Tezepelumab Reduces Oral Corticosteroid Use in Severe Asthma
A phase 3 trial demonstrates that tezepelumab significantly lowers daily oral corticosteroid dose in adults with severe, OCS-dependent asthma.
Tranexamic Acid Efficacy Varies by Breast Procedure Type
A retrospective cohort study clarifies which breast surgeries benefit from tranexamic acid for hematoma prevention.
Chronic Pain Mechanisms Show Distinct Cortical Connectivity Patterns
A study using TMS-EEG identifies neurophysiological differences across nociceptive, neuropathic, and nociplastic pain phenotypes.
THA Approaches Yield Similar Patient Outcomes, Distinct Gait Biomechanics
While patient-reported improvements are consistent across THA approaches, minimally invasive techniques offer specific early gait efficiency.
Amitriptyline Not Superior to Placebo for Leprosy-Related Neuropathic Pain
A randomized controlled trial found amitriptyline did not offer additional analgesia as add-on therapy for neuropathic pain in leprosy.
TMEM106B Variant Delays FTD Onset in GRN Mutation Carriers
A specific genetic variant significantly reduces FTD onset risk and extends median onset age by 14 years in GRN mutation carriers.
Muscle Cramp Impact Index Validated for Multidimensional Symptom Assessment
A new 14-item tool measures how muscle cramps interfere with sleep and daily life across neuromuscular, renal, and hepatic conditions.
Male Facelift Hematoma Rates Similar to Females With Standardized Protocols
A matched cohort analysis indicates that male facelift patients experience comparable hematoma rates to females when modern surgical protocols.