Weight Loss Intervention Safe in Older AF Patients, But Does Not Improve Symptoms
A randomized clinical trial indicates that while weight loss is achievable and safe in older, overweight AF patients, it may not reduce AF symptoms.
Individual LPFC Maps Reveal Fine-Grained, Interdigitated Networks
Precision fMRI in 10 individuals shows the lateral prefrontal cortex has a more fragmented and functionally distinct organization than group.
MIF Modulates Astrocyte Distribution in Schizophrenia Cortical Spheroids
A new study using patient-derived brain models identifies macrophage migration inhibitory factor (MIF) as a key regulator of astrocyte function.
Azithromycin Does Not Reduce Acute Wheezing Severity in Preschoolers
A multicenter trial found azithromycin offered no significant clinical benefit over placebo for moderate-to-severe wheezing symptoms.
Melittin Mitigates Doxorubicin-Induced Neurotoxicity in Murine Models
A study in mice suggests melittin, a bee venom component, reduces doxorubicin's neurotoxic effects by targeting inflammation and oxidative stress.
TSPO Deletion Reduces Cortical Spreading Depolarization in Mice
A new study in mice suggests that modulating translocator protein 18 kDa may influence CSD generation and associated neurovascular and inflammatory re
Low-Dose IL-2 Fails to Expand Tregs After Alemtuzumab in RRMS
A mechanistic study reveals that low-dose interleukin-2 alone does not boost regulatory T cells in alemtuzumab-treated multiple sclerosis patients.
Vertebrobasilar and Middle Cerebral Aneurysms Carry Highest Case Fatality Rates
A population-based study of 13,470 cases shows that aneurysm location significantly influences sudden death and 30-day mortality risks.
MSK1 Mediates BDNF Signaling in Striatal Development, Affecting Psychiatric-Relevant Behaviors
A new study identifies mitogen- and stress-activated kinase 1 (MSK1) as a key mediator in brain-derived neurotrophic factor (BDNF) pathways critical.
Inhaled Treprostinil Slows Lung Function Decline, Reduces Clinical Worsening in IPF
A phase 3 trial demonstrates that inhaled treprostinil significantly mitigates FVC reduction and clinical deterioration in patients with idiopathic.
Validating Generative AI Therapeutics: A Proposed Framework for Clinical Integration
A new framework outlines a multi-stage validation process to ensure the safety and efficacy of generative AI agents in mental health care.
Cerebellar iTBS Improves Post-Stroke Cognition via Dentate Nucleus-Ventromedial Thalamus Pathway
A mouse model study identifies the specific neural circuit mediating the cognitive benefits of intermittent theta-burst stimulation after stroke.