Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
Acute Care Surgery Fellowships Accelerate Military Surgical Readiness
A retrospective analysis indicates that AAST ACS fellowships enable general surgeons to meet military readiness standards within 12 months.
Stem Cell Dynamics Link to Epigenetic Aging Across Mammals
A new mathematical model connects stem cell activity to age-related DNA methylation patterns, offering a unified explanation for biological aging.
Widespread Cortical Alterations in Adolescent Early-Onset Psychosis
A large-scale mega-analysis reveals extensive structural brain differences in adolescents with early-onset psychosis compared to controls.
COPD Bronchoalveolar Lavage Reveals Specific Immune Cell Shifts Linked to Disease Severity
Single-cell sequencing identifies expanded macrophage, monocyte, and T-lymphocyte populations associated with airflow limitation and gas exchange.
MIPD Improves Early Postoperative Activity, Reduces Stress for Pancreatic Resection
A randomized trial shows minimally invasive pancreatoduodenectomy leads to higher physical activity and heart rate variability for weeks.
IL-6 Inhibition Shows Clinical Signals in Refractory Depression
A small trial of tocilizumab for difficult-to-treat depression suggests potential for symptom improvement and identifies patient selection markers.
Diabetes Worsens Bronchiectasis Outcomes, Increases Comorbidities and Infection Risk
A large registry analysis confirms diabetes significantly impacts disease severity, exacerbations, hospitalizations, and mortality in bronchiectasis.
Buried DIEP Flaps Show Similar Complication Rates to Skin Paddle Flaps
A retrospective review suggests completely burying deep inferior epigastric perforator flaps does not increase overall complication rates.
Anhedonia Severity Predicts Intermittent Theta-Burst Stimulation Response in MDD
Baseline anhedonia levels influence neurophysiological and clinical outcomes following iTBS for major depressive disorder.
Nasal Septal Perforation Impairs Olfactory and Trigeminal Function
A cross-sectional study links larger perforation areas and higher BMI to worse olfactory identification in patients with NSP.
Subsolid Lung Nodules Show High 5-Year Survival, Low Nodule-Related Mortality
A large cohort study clarifies the natural history and long-term outcomes of subsolid and ground-glass lung nodules.