Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
CTA Plaque-RADS Predicts Ipsilateral Recurrence in Embolic Stroke
A standardized scoring system for nonstenotic carotid plaques identifies a distinct ESUS subgroup with a threefold higher risk of recurrence.
US Adult Obesity Projected to Reach 47 Percent by 2035
An analysis of over 11 million adults reveals severe racial and geographic disparities as obesity rates continue to climb nationwide.
Maternal Depressive Symptoms Nearly Double Preeclampsia Risk
A meta-analysis of over 44,000 pregnancies shows early depressive symptoms significantly elevate the risk of hypertensive complications.
Hippocampus-Thalamus Circuit Drives Contextual Hyperactivity in PTSD Mouse Model
A specific glutamatergic pathway may be a therapeutic target for context-dependent arousal symptoms.
Consensus Algorithm Standardizes Rural Air Medical Transport Triage
A multidisciplinary panel used a Delphi survey to identify 18 patient factors and 6 interventions that warrant helicopter transport.
Oral Celecoxib and Ciprofloxacin Slow Functional Decline in ALS
A phase 2b trial shows the fixed-dose combination is safe and reduces the risk of severe complications over 18 months in early-stage ALS.
Nicotine Rewires Habenular Circuits in Mice, Altering Food Motivation
Chronic nicotine exposure in mice disrupts top-down control of the LDT-VTA cholinergic axis, driving exaggerated food-seeking behavior.
Vitamin C Reverses Depression-Like Behavior in Female Mice via D2 Receptors
A single dose of ascorbic acid restored dopamine D2 receptor signaling in the prefrontal cortex, rapidly alleviating depression in mice.
Inhibiting RhoA in Rat Prefrontal Cortex Reduces Morphine Dependence
Blocking the RhoA pathway in rats reduces opioid-induced neuroplasticity and limits glutamate spillover, offering a specific addiction target.
Epigenetic Target HDAC5 Reduces Environment-Triggered Cocaine Seeking in Rats
In a rat model, overexpressing the enzyme HDAC5 in the prelimbic cortex shifted synaptic balance to suppress context-driven cocaine seeking.
Cognitive Status Remains Key Predictor of Dementia Risk Alongside p-tau181
ARIC data show that while p-tau181 is prognostic, the absolute risk of dementia remains low in cognitively unimpaired individuals.