Brepocitinib 30 mg Improves Dermatomyositis Symptoms and Reduces Glucocorticoid Need
A phase 3 trial shows that once-daily oral brepocitinib 30 mg significantly improves disease activity and allows for glucocorticoid tapering in adults
Nitrous Oxide Addiction Linked to DCN-VTA Circuit, AMPA Receptor Potentiation
A new study identifies how nitrous oxide directly enhances AMPA receptor function in the DCN-VTA circuit, mediating its rewarding effects.
Nitrous Oxide Reward Driven by DCN-VTA Circuit, AMPA Receptor Potentiation
A new study in animal models identifies the specific neural circuit and molecular mechanism underlying nitrous oxide's rewarding effects.
IDH1 Mutations in Prostate Cancer Link High Stage/Grade to Favorable Outcomes
A retrospective analysis identifies IDH1 mutations as a marker for improved survival in prostate cancer, despite aggressive initial presentation.
CPES Score May Better Identify PE Patients Needing Advanced Intervention
A retrospective study suggests the Composite Pulmonary Embolism Shock score offers improved prediction for advanced interventions in PE.
CPES Score Identifies PE Patients Needing Advanced Intervention
A retrospective study finds the Composite Pulmonary Embolism Shock score particularly effective in predicting the need for advanced therapies.
Urinary Nanoprobe Detects Therapy-Induced Senescence in Lung Cancer, Fibrosis
A new injectable albumin-based nanoprobe allows noninvasive, longitudinal monitoring of cellular senescence burden via urine testing.
GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
PsA Improvement Thresholds Vary by Baseline Disease Activity, Not Prior TNFi Exposure
Minimal clinically important improvement (MCII) thresholds in psoriatic arthritis depend on baseline disease severity, guiding personalized treatment.
Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.
UK and Ireland Neonatal Stroke Incidence: 9.0 per 100,000 Live Births
A new surveillance study details the epidemiology, clinical patterns, and short-term outcomes of neonatal stroke in the UK and Ireland.
UK Neonatal Stroke Incidence: 9.0 per 100,000 Live Births, Varied Presentations
A new surveillance study details the incidence, clinical features, and initial management of neonatal stroke in the UK and Ireland.