ACL Reconstruction Triples 20-Year Risk of Knee Arthroplasty
A study of 135,881 patients shows a 2.44% absolute risk of knee replacement two decades after surgery, rising with meniscal involvement.
Quality Improvement Shortens Time to Antibiotics in Pediatric Intestinal Failure
Multidisciplinary interventions reduced median cephalosporin delivery time by 58% for children with suspected central line infections.
Glofitamab Shows High Response Rates in Refractory Aggressive B-Cell Lymphoma
Real-world data link baseline CD4+ effector T cells and early CD8+ expansion to improved outcomes with bispecific antibody therapy.
Auditory Slow-Wave Stimulation Reduces Axonal Damage in Rat Brain Injury Model
Closed-loop acoustic triggers during deep sleep preserved white matter integrity and cognitive function in a preclinical study of TBI.
Biliopancreatic Diversion Shows Durable Weight Loss but High Long-Term Morbidity
A 50-year cohort study finds universal diabetes remission and sustained weight loss alongside an 86% nutritional complication rate.
Early Chelation Prevents Cardiac Iron Overload in Diamond–Blackfan Anemia
A retrospective study of 64 infants shows that initiating chelation at a median age of 18 months reduces ferritin and protects the heart.
Paramedic Discharge Protocols Reduce Call Times but Remain Underutilized
Prehospital discharge for resolved seizures and hypoglycemia cuts call duration by half compared to emergency department transport.
Hugo Robotic System Achieves High Success in US Hernia Repair Trial
A multi-center study of 193 patients shows zero conversions and low surgical-site event rates for inguinal and ventral hernia repairs.
Brain Connectivity Subtypes Predict rTMS Response for Anhedonia in Depression
Patients with specific frontoparietal hyperconnectivity show significant improvement in anhedonia following neurostimulation.
Early Radiographic Response Poorly Predicts Local Control in Brain Metastases
A large cohort study finds that stable disease and partial response carry similar recurrence risks after radiation therapy.
IVC to Aorta Ratio Tracks Fluid Response but Lacks Clinical Correlation
Ultrasound metrics of the inferior vena cava change after fluid boluses in pediatric shock but do not align with heart rate or shock index.
CDR132L Fails to Improve Ventricular Volume After Myocardial Infarction
A phase 2 trial of the microRNA-132 inhibitor CDR132L showed no significant benefit in structural or functional endpoints at six months.