Non-Intubated ECMO Failure Linked to Seven-Fold Increase in 90-Day Mortality
An international cohort study finds that while avoiding mechanical ventilation during ECMO is feasible, failure carries high mortality risks.
CEP41 Mutations Alter Cortical Neuron Ratios in Human Organoid Models
The R242H mutation shortens primary cilia and disrupts the balance of excitatory and inhibitory neurons during brain development.
Active Support Increases Injury Prevention Program Use in Female Athletes
In-person workshops for coaches tripled the use of injury prevention protocols, though direct impact on ACL and concussion rates remains unclear.
Hookwire Localization Enables Wedge Resection for Hilar-Proximal Nodules
A multicenter study shows CT-guided localization and ultrasonic dissection allow for safe, lung-sparing excision of small hilar lesions.
CGRP Inhibitors Reduce Glaucoma Risk Compared to Traditional Migraine Preventives
A large cohort study finds monoclonal antibody CGRP inhibitors lower incident glaucoma risk by 25% over three years.
Sentinel Node Biopsy Reduces Axillary Dissection in cN1 Breast Cancer
A clinical trial shows 76% of patients with palpable nodes and HR+/HER2- disease can avoid full dissection using upfront biopsy.
Multiarm Platform Evaluates Traumatic Wound Care During War in Ukraine
Researchers implement a multistage protocol to test devices and therapies for infected wounds amid rising antimicrobial resistance.
Troponin I to T Ratio Distinguishes Acute Necrosis From Chronic Injury
A multicohort study finds the troponin ratio identifies lethal cell death and improves differentiation of type 1 and 2 myocardial infarction.
Adolescent Depression Linked to Declining Amygdala-Prefrontal Connectivity
Longitudinal imaging shows that escalating depressive symptoms correlate with weakening frontolimbic links during emotion regulation.
US Vitiligo Patients Experience Brief Treatment Durations and High Untreated Rates
A retrospective cohort study of 24,949 patients reveals significant gaps in long-term management and frequent use of short-term therapies.
Elective Microaxial Flow Pump Does Not Improve High-Risk PCI Outcomes
A randomized trial finds no clinical benefit and a potential mortality signal with routine mechanical unloading during complex revascularization.
Microaxial Flow Pump Fails to Improve Outcomes in High-Risk PCI
A randomized trial of 300 patients shows elective left ventricular unloading does not reduce major adverse events at 12 months.