Critical Illness Linked to Significant Income Loss and Unemployment
A nationwide cohort study of 582,341 survivors reveals that over 10% face catastrophic financial decline despite universal coverage.
Deep Learning Automates PET RANO Criteria Extraction in Glioma Imaging
An externally validated model achieves high agreement with experts in quantifying metabolic tumor volume and tumor-to-background ratios.
Type 2 Diabetes Linked to Reduced Effort-Based Motivation Unchanged by Semaglutide
A computational study finds metabolic dysfunction drives a cognitive shift toward energy conservation regardless of GLP-1 agonist use.
Integrated Genetics and MRD Guide Transplant in Ph-Negative ALL
A prospective study shows that combining genetic risk with early molecular response identifies adults who can safely avoid transplantation.
Abrocitinib Shows Faster Itch Relief Than Dupilumab in Atopic Dermatitis
A post hoc analysis of JADE trials finds oral JAK1 inhibition reaches an itch-free state sooner, correlating with better sleep and quality of life.
Pure Autonomic Failure Carries 5% Annual Risk of Central Phenoconversion
A meta-analysis identifies hyposmia and sleep disturbances as key predictors of progression to Parkinson disease or multiple system atrophy.
Management Consultants Show No Benefit for Hospital Finances or Patient Outcomes
A study of 306 nonprofit hospitals found that $7.8 billion in consulting fees did not improve margins, operations, or clinical quality.
Paramedic Decisions to Withhold Trauma Resuscitation Match Autopsy Findings
A retrospective review of 90 traumatic cardiac arrest cases shows high diagnostic specificity in field assessments of non-survivable injury.
Microglial Activation Disrupts Hippocampal Memory Consolidation in Aged Mice After Surgery
Surgical stress triggers neuroinflammation that inhibits CA3 to CA1 signaling, reducing sharp-wave ripples essential for memory.
Heartbeat Evoked Potential Lacks Consistency for Clinical Use
A meta-analysis finds that methodological variability prevents using this neural marker of interoception as a reliable diagnostic tool.
Veterans Hospitalized for Alcohol Use Disorder Often Miss Medication Initiation Opportunities
A study of 29,041 hospitalizations found that only 30.8% of veterans received medications like naltrexone during or shortly after discharge.
Automated Software Matches Clinician Accuracy in Peri-operative Echocardiography
A multicenter study shows high agreement between AI-driven analysis and expert measurements for ejection fraction and valvular disease.