24-Hour Blood Pressure Variability Linked to Cognitive Decline and Brain Aging
Fluctuations in ambulatory blood pressure correlate with impaired executive function and blood-brain barrier leakage in older adults.
Fetal MRI Scoring System Quantifies Severity in Trisomy 13, 18, and CHARGE
A new morphological score and network analysis map phenotypic heterogeneity to assist in prenatal counseling and management planning.
Cutaneous pTDP-43 Deposits Distinguish ALS From Other Neuropathies
Skin and tongue biopsies detect phosphorylated TDP-43 pathology that correlates with clinical disease stage in patients with ALS.
Family Functioning Influences Prenatal Bonding Directly and via Depressive Symptoms
A multicenter study of 261 pregnant women shows that family dynamics shape the emotional quality of maternal-fetal attachment.
Forefoot MRI Pacinian Corpuscle Count Correlates With Diabetic Neuropathy Severity
Loss of mechanoreceptors on routine imaging mirrors electrophysiological deficits in large-fiber sensory dysfunction.
Status Epilepticus Mortality Rises in the United States Since 2007
A 22-year analysis of CDC data reveals increasing death rates and significant racial and regional disparities in status epilepticus.
Condition-Based Monitoring Reduces Depression Incidence and Improves Treatment Response
A multi-domain framework utilizing C-reactive protein and autonomic monitoring aims to bridge the intervention gap in preventive psychiatry.
Fibrotic Lung Abnormalities Linked to Increased Coronary Artery Calcification
A retrospective study of 2,031 screening participants finds interstitial lung changes correlate with subclinical atherosclerosis burden.
Telehealth Hypnotic Cognitive Therapy Reduces Chronic Pain After Spinal Cord Injury
A randomized trial demonstrates that remote delivery of hypnotic cognitive therapy significantly lowers pain intensity and depression.
Radiomics Models Predict Ablative Radiotherapy Response in Oligometastatic Disease
A scoping review of 29 studies shows deep learning models achieve high accuracy in predicting treatment response, primarily for brain metastases.
RNA Interference Normalizes PAI-1 Levels and Prolongs Lifespan in Murine Models
A single dose of siRNA-lipid nanoparticles achieved 90% knockdown of plasma PAI-1, reducing thrombus weight and increasing survival in mice.
FFR-Guided PCI Costs 30% Less Than Surgery for 3-Vessel Disease
A FAME 3 analysis shows fractional flow reserve-guided stenting yields equivalent quality-adjusted survival and faster functional recovery.