Gut Microbiome Signatures Improve Nasopharyngeal Carcinoma Detection
Metagenomic analysis identifies microbial markers that enhance the diagnostic accuracy of Epstein-Barr virus DNA for nasopharyngeal cancer.
Retinal Imaging AI Screens for Six Systemic Metabolic and Endocrine Diseases
A multitask framework identifies diabetes, hypertension, and osteoporosis from fundus photos, showing high negative predictive value in primary care.
Outpatient Oncology Records Lack Goals-of-Care Documentation for Most Older Adults
A retrospective study of 7,743 patients found that only 43% had documented goals-of-care conversations in their electronic health records.
Intravenous NAD+ Reduces Post-Resuscitation Lung Injury in Swine Model
Exogenous NAD+ administration improves oxygenation and limits pulmonary edema by inhibiting ferroptosis-mediated cell death.
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Spectral CT Reconstructions Improve Acute Bowel Ischemia Detection
Adding iodine maps and monoenergetic images to portal venous CT increases diagnostic accuracy from 73% to 86% across scanner platforms.
MRI Index Quantifies Alzheimer’s Pattern to Predict Dementia Onset
A structural brain vulnerability index identifies early neurodegeneration and predicts conversion from mild cognitive impairment.
VEGFR1 Blockade Reverses Advanced Diabetic Kidney Damage in Mice
Selective inhibition of VEGFR1 regresses histological lesions and improves survival in murine models of progressive renal failure.
Patellar Resurfacing Shows No Clinical Advantage in Propensity-Matched TKA Analysis
A large-scale study finds equivalent patient-reported outcomes and complication rates whether or not the patella is resurfaced.
Prenatal Depression Does Not Alter Infant Oral Microbiome at Birth
A cohort study of 324 mother-infant pairs finds no link between maternal affective symptoms and neonatal microbial diversity or composition.
Lithuanian Liebowitz Social Anxiety Scale Shows High Reliability in Young Adults
A validation study of the self-report version finds strong internal consistency but suggests total scores are most robust for assessment.