Ultrasound-Derived Fat Fraction Accurately Grades Steatosis in Chronic Liver Disease
A multicenter study shows ultrasound-derived fat fraction provides high diagnostic accuracy across diverse etiologies and fibrosis stages.
Targeted sFlt-1 Apheresis Safely Extends Pregnancy in Very Preterm Preeclampsia
A pilot trial shows selective removal of sFlt-1 reduces maternal blood pressure and delays delivery by a median of 10 days.
Genetic Risk Factors Directly Link to Pediatric Suicidality Independent of Symptoms
Polygenic scores for internalizing and externalizing traits reveal direct and mediated pathways to suicidal ideation and attempts in youth.
Astrocytic Hemichannel Overactivity Drives Prefrontal Circuit Deficits in Schizophrenia Models
Elevated connexin 43 in the prefrontal cortex triggers excessive glutamate release, offering a potential non-neuronal therapeutic target.
Nipple Punch Grafts and Tattooing Improve Aesthetic Outcomes in Mastectomy
A pilot study shows combining punch grafts with 3D tattooing yields higher aesthetic ratings and fewer scars than traditional grafting.
Absence of Chest Pain Predicts Severe Pediatric Myocarditis Risk
A retrospective study identifies hemodynamic instability and elevated procalcitonin as key markers for ICU admission in children.
Conduction System Pacing Reduces Hospitalization and Improves Ejection Fraction
New data suggest direct stimulation of the His bundle or left bundle branch improves outcomes over traditional biventricular pacing.
Abdominal Contractions Drive Brain Motion and Fluid Clearance in Mice
A hydraulic link between the abdomen and cranium suggests physical activity mechanically facilitates interstitial fluid drainage.
Delaying Infant Hepatitis B Vaccination Increases Infections and Costs
A Markov model of 3.6 million infants shows even a two-month delay in the birth dose raises mortality and healthcare expenditures.
Oral Factor D Inhibitor Fails to Improve Myasthenia Gravis Symptoms
A phase 2 trial of vemircopan was terminated after the oral complement inhibitor showed no significant benefit over placebo.
Continuous Probabilities Identify High-Risk Patients in Hypoinflammatory Respiratory Failure
Continuous modeling of IL-6 and sTNFR-1 reveals a 40% mortality risk in patients masked by binary inflammatory classification.
WNK1-mTORC2 Pathway Regulates Murine Potassium Secretion Independently of Aldosterone
Selective disruption of WNK1 or mTORC2 in the distal nephron impairs potassium excretion and causes hyperkalemia in mice.