Responsive Neurostimulation Reduces Focal Seizures by 82% at Three Years
A prospective postapproval study of 324 adults shows real-world seizure reduction exceeds initial clinical trial results.
Sublobectomy Extends Survival in IDH-Wildtype Glioblastoma
A retrospective study shows supramaximal resection within functional limits improves survival without increasing neurological deficits.
Low MicroRNA-362 Linked to Acute Lung Injury After Murine Brain Trauma
Downregulation of microRNA-362-3' in extracellular vesicles fails to suppress proinflammatory TIMP-1 in a mouse model of head injury.
Cementless Total Knee Arthroplasty Matches Cemented Survivorship at Five Years
A comparative study of 483 procedures shows no difference in aseptic revision rates or radiographic stability between fixation methods.
GDF-15 Predicts Depressive Symptoms in Adults Aged 72 and Older
A longitudinal study finds that growth differentiation factor 15 correlates with depression severity only in geriatric populations.
Changing Surgical Approach During Infection Treatment Does Not Increase Failure Risk
A multicenter study finds that switching surgical corridors for hip infection management maintains high eradication and stability rates.
Caregiver Strain Mediates Alpha Wave Activity in Children With ADHD
Subjective internalized caregiver stress links clinical attention deficits to posterior alpha power, suggesting environmental modulation.
Basal Ganglia Perivascular Spaces Predict Long-Term Executive and Visuospatial Decline
A decade-long study identifies perivascular spaces as an independent marker of cognitive deterioration, distinct from other vascular lesions.
First-Time Seizure Linked to Increased Risk of Systemic and Neurological Cancer
A Danish cohort study finds a fivefold increase in overall cancer risk within one year of an initial seizure in adults.
Non-Invasive Tools Estimate Intracranial Pressure When Invasive Monitoring Is Contraindicated
A review evaluates ultrasound and imaging techniques to detect intracranial hypertension in patients with coagulopathy or liver failure.
Pulsed Field Ablation Reduces Recurrence in Persistent Atrial Fibrillation
First-line pulsed field ablation showed a 56% success rate at 12 months compared to 30% for antiarrhythmic drugs in a randomized trial.
Biopsy Identifies Non-Diabetic Disease in 59% of Diabetic Patients
A 49,075-patient analysis shows non-diabetic kidney disease reduces the risk of end-stage renal failure by more than half.