Glofitamab Shows 75% Response Rate in Refractory CNS Lymphoma
Real-world data demonstrate measurable drug penetration and the utility of liquid biopsy for monitoring treatment response.
Molecular Markers in Rathke’s Cleft Cysts Correlate With Endocrine Deficits
A retrospective study of 108 patients identifies FOXJ1 and TUBA1A as indicators of hypopituitarism and vasopressin deficiency.
Subliminal Threat Cues Trigger Sustained Social Avoidance in Women
Eye-tracking data reveals that unconscious perception of anger or disgust leads to reduced visual engagement with subsequent happy faces.
Acetabular Retention in Hip Resurfacing Conversion Shows 10-Year Durability
Retaining the cup during conversion to total hip arthroplasty maintains 100% component survival but carries high infection risks.
Sutureless Prosthetic Capsular Bag Stabilizes Lenses in Eyes Without Zonular Support
A first-in-human study of 15 patients shows stable refractive outcomes and low complication rates using a trans-scleral fixation device.
MIGS Reduces Intraocular Pressure 20% to 50% in Angle-Closure Glaucoma
Minimally invasive techniques combined with lens extraction offer a safer alternative to trabeculectomy by targeting specific anatomy.
Automated MRI Segmentation Establishes Brain Volume Norms for Very Preterm Infants
Sex-stratified reference ranges for 26 brain regions provide a clinical baseline to identify developmental deviations at term-equivalent age.
Targeted Hepatitis B Birth Vaccination May Increase Neonatal Infections
A simulation of 3.6 million infants suggests replacing universal birth doses with targeted strategies could add 628 neonatal infections.
Alternating Venetoclax Triplets Extend Survival in Older AML Patients
A phase 2 trial shows a 45% five-year survival rate and high rates of deep molecular remission using an alternating low-intensity regimen.
Oncology Care Model Linked to Reduced Therapy in Poor-Prognosis Cancer
Medicare's episode-based payment model did not increase treatment volume and significantly lowered spending for patients with late-stage disease.
Mailed FIT-DNA Increases Colorectal Cancer Screening Rates in Community Health Centers
A pragmatic trial shows mailed FIT-DNA outreach achieves higher screening uptake than standard FIT, though follow-up colonoscopy rates remain low.
Subthalamic Nucleus Predominantly Facilitates Action in Primate Models
Electrophysiological data show 89 percent of task-related neurons in the subthalamic nucleus promote rather than inhibit motor choices.