Cytotoxic T Cells Expand in Antibody-Mediated Kidney Transplant Rejection
Clonal T cell expansion occurs in antibody-mediated rejection even without histological evidence of T cell-mediated rejection.
Lebrikizumab Maintains 48-Week Efficacy in Systemic-Naive and Experienced Atopic Dermatitis
A prospective study of 187 patients shows high response rates, though prior systemic therapy may limit clearance in head and neck lesions.
Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
Repeat OnabotulinumtoxinA for Masseter Prominence Does Not Alter Mandibular Bone
A 12-month placebo-controlled trial using CT imaging shows no significant bone remodeling after masseter injections for facial contouring.
Artificial Intelligence Matches Physician Committees in Adjudicating Cardiovascular Trial Endpoints
An automated system shows high agreement with human experts in identifying major adverse cardiovascular events in a large clinical trial.
Recurrent Renal Cell Carcinoma Downregulates MHC-I After Adjuvant Atezolizumab
Molecular analysis of IMmotion010 samples suggests a shift toward VEGF-targeted therapy when tumors recur after checkpoint inhibition.
Trabeculectomy Slows Visual Field Loss Better Than Medication in Advanced Glaucoma
A five-year trial shows surgery preserves monocular vision but finds no significant difference in patient-reported quality of life.
Serum Neurofilament Light Chain Tracks Acute Injury in Refractory Status Epilepticus
Elevated NfL levels distinguish cryptogenic NORSE from other seizure etiologies and correlate with poor functional outcomes at discharge.
Heterogeneous Trial Endpoints Limit Evidence in Acute Kidney Injury
A review of 251 trials reveals inconsistent outcome definitions and measurements that hinder clinical application of renal research.
Gastric Bypass Reversal Relieves Symptoms but Carries High Morbidity Risk
A Swedish cohort study shows 86% symptom relief after reversal, though one in four patients faces early severe complications.
Higher Daily Step Counts Linked to Reduced Bradykinesia and Increased Dyskinesia
Objective wearable data from 80 patients shows a correlation between physical activity and motor symptom trade-offs in Parkinson's disease.