Central Macular Lesion Extent Predicts Quality of Life in Geographic Atrophy
Phase III trial data show atrophy within the central 2.50-mm zone drives functional impairment more than the surrounding retinal area.
Dual-Microphone Audio Processors Improve Mandarin Speech Recognition in Noise
Upgrading to SONNET 2 or RONDO 3 processors significantly enhances sentence and word recognition for Mandarin-speaking cochlear implant users.
CT Vascular Pruning Markers Identify Chronic Vasculopathy in Sickle Cell Disease
Automated quantification of small pulmonary vessels correlates with impaired gas exchange and history of pulmonary hypertension.
Wind Instruments Trigger Intraocular Pressure Spikes During High-Pitch Play
A cross-sectional study of 63 musicians finds transient ocular hypertension in wind players independent of the Valsalva maneuver.
Blood MicroRNA Signatures Correlate With Hippocampal Volume and Atrophy Rates
Specific microRNA expression patterns in whole blood may serve as early markers for structural brain changes and neurodegenerative risk.
Physical Therapy Improves Function More Than CBT in Chronic Low Back Pain
A sequential randomized trial finds physical therapy superior for initial functional gains, though secondary strategies show no difference.
Occult Hypertension Linked to Coronary Plaque in Male Masters Athletes
Hidden hypertension and exercise-induced blood pressure spikes correlate with high-risk coronary atherosclerosis in asymptomatic athletes.
Counterconditioning Stabilizes Neural Safety Signals in PTSD
Functional MRI shows pairing threat stimuli with positive outcomes reinforces safety patterns in the ventromedial prefrontal cortex.
Deep Learning Synthesizes Contrast-Enhanced CT and MRI Scans
A scoping review of 56 studies shows high image fidelity but limited evidence for diagnostic interchangeability in clinical practice.
Early Palliative Referral Improves End-of-Life Care Regardless of Visit Frequency
Timing of referral for metastatic solid tumors significantly impacts hospice enrollment and ICU use more than the total number of visits.
Peritruncal Blood Volume Predicts Shunt Dependency and Functional Recovery in aSAH
Infratentorial hematoma volume shows stronger associations with long-term outcomes than traditional Fisher scales in subarachnoid hemorrhage.
Subjective Cognitive Deficits Predict Poor Antidepressant Response in MDD
Smartphone-based monitoring of patient-reported cognitive dysfunction identifies outpatients at risk for suboptimal treatment outcomes.