High-Ratio Plasma Resuscitation Reduces Mortality in Moderate Traumatic Brain Injury
A large database analysis suggests plasma-heavy transfusion improves 30-day survival for patients not requiring massive transfusion.
Proximal Nerve Stimulation Improves Sleep Apnea in CPAP-Intolerant Patients
A randomized trial shows proximal hypoglossal nerve stimulation significantly reduces apnea-hypopnea index and daytime sleepiness.
Risk-Weighted Impact Metric May Reduce Overtreatment of Incidental Aneurysms
A simulation study shows that accounting for the timing of adverse events preserves quality-adjusted life years compared to standard models.
Optimal Sleep Duration Mitigates Five-Fold Dementia Risk in Focal Epilepsy
A UK Biobank study finds 6 to 8 hours of sleep significantly preserves executive function and reduces dementia risk in epilepsy patients.
Long Bone Bowing Reclassifies Seventy Percent of Valgus Knee Phenotypes
Radiographic analysis shows metaphyseal bowing drives valgus alignment, suggesting many cases are extra-articular rather than joint-based.
Machine Learning Model Predicts One-Year Rehospitalization in Preterm Infants
A retrospective study of 2,226 infants identifies clinical and socioeconomic factors linked to a 16.1% readmission rate.
Integrated DNA Drives Surface Antigen Production in HBeAg-Negative Hepatitis B
Liver tissue analysis reveals that integrated viral DNA, not replication-active reservoirs, sustains surface antigen in later disease stages.
Chronic Back Pain Linked to Sensory Cortex Hyperactivity During Walking
Patients with nonspecific low back pain show increased neural load in somatosensory regions and reduced gait velocity during dual tasks.
Genetic Diagnosis and Multisuture Fusion Predict Chiari Risk in Lambdoid Synostosis
Longitudinal data suggest routine MRI screening is unnecessary for isolated unilambdoid synostosis but essential for multisuture cases.
Arteriovenous Access Shows Lower Mortality Risk Than Catheters in Hemodialysis
A study of 146,967 patients suggests the survival gap between access types may stem from baseline health rather than the access itself.
Luvadaxistat Fails to Improve Schizophrenia Cognition in Phase 2 Trial
The ERUDITE study found no significant cognitive benefit from adding the D-amino acid oxidase inhibitor to stable antipsychotic therapy.
CSF Outflow Resistance and Callosal Angle Predict iNPH Shunt Outcomes
Elevated fluid resistance and preserved preoperative cognition correlate with sustained functional gains after ventriculoperitoneal shunting.