Sublobectomy Extends Survival in IDH-Wildtype Glioblastoma
A retrospective study shows supramaximal resection within functional limits improves survival without increasing neurological deficits.
Low MicroRNA-362 Linked to Acute Lung Injury After Murine Brain Trauma
Downregulation of microRNA-362-3' in extracellular vesicles fails to suppress proinflammatory TIMP-1 in a mouse model of head injury.
Basal Ganglia Perivascular Spaces Predict Long-Term Executive and Visuospatial Decline
A decade-long study identifies perivascular spaces as an independent marker of cognitive deterioration, distinct from other vascular lesions.
First-Time Seizure Linked to Increased Risk of Systemic and Neurological Cancer
A Danish cohort study finds a fivefold increase in overall cancer risk within one year of an initial seizure in adults.
Non-Invasive Tools Estimate Intracranial Pressure When Invasive Monitoring Is Contraindicated
A review evaluates ultrasound and imaging techniques to detect intracranial hypertension in patients with coagulopathy or liver failure.
Glofitamab Shows 75% Response Rate in Refractory CNS Lymphoma
Real-world data demonstrate measurable drug penetration and the utility of liquid biopsy for monitoring treatment response.
Automated MRI Segmentation Establishes Brain Volume Norms for Very Preterm Infants
Sex-stratified reference ranges for 26 brain regions provide a clinical baseline to identify developmental deviations at term-equivalent age.
Subthalamic Nucleus Predominantly Facilitates Action in Primate Models
Electrophysiological data show 89 percent of task-related neurons in the subthalamic nucleus promote rather than inhibit motor choices.
Serum Neurofilament Light Chain Tracks Acute Injury in Refractory Status Epilepticus
Elevated NfL levels distinguish cryptogenic NORSE from other seizure etiologies and correlate with poor functional outcomes at discharge.
Higher Daily Step Counts Linked to Reduced Bradykinesia and Increased Dyskinesia
Objective wearable data from 80 patients shows a correlation between physical activity and motor symptom trade-offs in Parkinson's disease.
Schizophrenia Subtype Shows Low Striatal Dopamine and Iron Accumulation
A frontotemporal dementia-like phenotype in schizophrenia patients challenges the universal hyperdopaminergic model of the disease.
Brain-Responsive Neurostimulation Reduces Focal Seizures by 82% at Three Years
A prospective real-world study shows higher seizure reduction rates and lower SUDEP risk than observed in initial clinical trials.