Platelet mTOR Pathway Drives Neuropathogenesis in Cerebral Malaria
A new study identifies the mechanistic target of rapamycin (mTOR) in platelets as a key mediator of brain injury in experimental cerebral malaria.
Exome Sequencing Identifies Genetic Links in Persistent Tachypnea of Infancy
Comprehensive genetic testing reveals that persistent tachypnea of infancy often associates with underlying neurodevelopmental conditions.
CANMAT launches 2024 guideline for Perinatal Mood, Anxiety, and Related Disorders
The new CANMAT guideline emphasizes routine, systematic screening for perinatal mood and anxiety disorders throughout pregnancy and up to one year.
Pediatric Burn Length of Stay Lower Than Traditional Benchmarks
A multi-institutional analysis of 1,543 pediatric burn patients updates expected hospital stay per TBSA, identifying key influencing factors.
Lamotrigine-Topiramate Duotherapy Increases Congenital Malformation Risk Fourfold
A large registry study identifies a significant risk increase for specific antiseizure drug combinations used during the first trimester.
Biallelic EIPR1 Variants Cause Neurodevelopmental Syndrome and Neutropenia
Defects in endosomal recycling and dense core vesicle biogenesis drive a spectrum of microcephaly, ataxia, and spasticity.
Hong Kong Genome Project Identifies Population-Specific Genetic Variants, Informs Prescriptions
A large-scale genomic initiative in the Chinese population reveals diagnostic rates for rare diseases and pharmacogenomic insights.
Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department
EUSEM launches 2025 guideline for Acute Pain Management in Emergency Situations
This updated guideline fundamentally shifts acute pain management in emergency settings towards multimodal, non-opioid first-line therapies.
Dose-Sparing Polio Vaccine Matches Full-Dose Immunogenicity and Safety in Infants
An adjuvanted inactivated poliovirus vaccine with reduced antigen content demonstrates comparable immune response and safety to standard IPV.
Autism Subtypes Linked to Distinct Brain Connectivity and Biological Pathways
A cross-species neuroimaging study identifies two replicable autism subtypes with specific functional connectivity patterns and biological underpinnin
SHANK3 Haploinsufficiency in Macaques Reveals Diverse Behavioral, Cognitive Phenotypes
A new macaque model of SHANK3 haploinsufficiency provides insights into Phelan-McDermid syndrome and potential biomarkers.