Ivermectin Fails to Improve Outcomes in Hospitalized COVID-19 Patients
A randomized trial shows no benefit for organ support-free days or survival in critically and noncritically ill patients.
Robotic Kidney Transplant Reduces Complication Rates in Randomized Trial
A Danish study finds robot-assisted surgery lowers major and vascular complications by approximately 10 percent compared to open surgery.
Strengthening and Stretching Yield Similar Quality of Life Gains in Hip Impingement
A randomized trial finds targeted strengthening improves pain perception and muscle force more than stretching, despite equal quality of life scores.
Individualized Algorithm Lowers Achilles Rerupture Risk and Limits Unnecessary Surgery
The CARTA protocol uses ultrasound criteria to select patients for surgery, reducing reruptures by 73% compared to non-operative management.
Higher Ivermectin Dose Does Not Improve Severe Scabies Cure Rates
A randomized trial shows 400 μg/kg of ivermectin plus permethrin is not superior to the standard 200 μg/kg dose for crusted scabies.
Ketamine Shows No Sustained Hemodynamic Advantage Over Propofol During Intubation
A randomized trial in critically ill patients found that ketamine-induced blood pressure benefits were transient and did not improve survival.
MRNA Influenza Vaccine Reduces Infection Risk in Adults Over 50
A phase 3 trial found mRNA-1010 superior to standard vaccines, though it caused more frequent transient systemic reactions.
Mindfulness Adjunct Lowers Anxiety Scores in Medicated Adults With GAD
An 8-week mindfulness program added to pharmacotherapy improved clinician-rated anxiety, sleep quality, and psychosocial functioning.
Prefrontal Stimulation Amplifies Placebo Mood Response in Depression
Intermittent theta burst stimulation of the dorsomedial prefrontal cortex modulates the default mode network to enhance expectancy effects.
One-Liter PEG-Ascorbate Improves High-Quality Inpatient Bowel Cleansing
A randomized trial shows very low-volume preparation yields superior right-colon visualization compared to 2-liter and 4-liter regimens.
Manual Pressure Augmentation During Defibrillation Does Not Improve Survival
A randomized trial found that while manual pressure reduces transthoracic impedance, it does not increase survival to hospital discharge.
Restrictive Sepsis Resuscitation Shows No Long-Term Functional Deficits
A randomized trial finds similar cognitive and physical outcomes at 12 months for restrictive versus liberal fluid strategies in sepsis.