Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Randomized Controlled Trial
Triplet Immunotherapy Shows Durable Response in Relapsed Hodgkin Lymphoma
Adding ipilimumab to nivolumab and brentuximab vedotin may improve long-term disease control for patients deferring stem cell transplant.
Randomized Controlled Trial
APT-Sepsis Program Lowers Maternal Infection Mortality and Morbidity
A cluster-randomized trial of 431,394 women shows a 32% reduction in severe infection-related outcomes using a standardized care bundle.
Randomized Controlled Trial
Cortical Stimulation Reduces Overactive Bladder Symptoms After Stroke
A randomized trial shows low-frequency rTMS improves urinary function and quality of life while lowering societal costs.
Randomized Controlled Trial
Group CBT Reduces Hostile Attribution Bias in Young Adults With ASD Traits
A pilot study finds that targeting social cognitive distortions improves communication and quality of life through distinct pathways.
Randomized Controlled Trial
Digital Exercise and Interoceptive Training Lower Acute Depression Scores in Young Adults
A randomized trial found significant short-term symptom reduction, though benefits did not persist at one- or three-month follow-up.
Randomized Controlled Trial
Delayed Angiography Safe in Cardiac Arrest Without ST-Segment Elevation
Five-year COACT trial data show no survival difference between immediate and delayed coronary angiography for resuscitated patients.
Randomized Controlled Trial
Evolocumab Reduces First Cardiovascular Events in High-Risk Diabetes
In patients with diabetes and no known atherosclerosis, adding evolocumab to statins lowered the 5-year risk of major events by 2.1%.
Randomized Controlled Trial
Iron Bioresorbable Scaffolds Match Metallic Stents for Late Lumen Loss at Two Years
A randomized trial in China finds iron-based scaffolds achieve similar vascular patency and flow to standard stents despite higher revascularization.
Non-Randomized Controlled Trial
Oral Nicotinamide Mononucleotide Increases Platelets in Refractory Immune Thrombocytopenia
A phase 1/2 trial shows oral NMN modulates the CD38-NAD+ axis to improve platelet counts while preserving humoral immunity.
Randomized Controlled Trial
Group Cognitive Therapy Reduces Negative Symptoms in Early Psychosis
A pilot trial shows rumination-focused therapy added to standard care significantly improves negative symptoms and repetitive thinking.
Randomized Controlled Trial
Biomarkers Predict Kidney Response to Belimumab in Lupus Nephritis
A Phase 3 post hoc analysis identifies baseline IgA, anti-C1q, and early proteinuria changes as key indicators of treatment success.
Randomized Controlled Trial
Distributed HABIT-ILE Dosing Matches Massed Therapy for Bilateral Cerebral Palsy
Spreading 90 hours of intensive bimanual and lower extremity therapy over 15 weeks yields functional gains equivalent to 3-week programs.
Randomized Controlled Trial
Mim8 Prophylaxis Reduces Bleeding in Hemophilia A with or without Inhibitors
Phase 3 data show weekly or monthly subcutaneous Mim8 significantly lowers bleeding rates compared to on-demand and prior factor therapy.
Randomized Controlled Trial
Intranasal Ketamine Reduces Existential Distress in Advanced Cancer Patients
Secondary analysis shows three doses of intranasal ketamine improve death-related anxiety and existential well-being in palliative care.
Randomized Controlled Trial
Behavioral Activation Reduces Pain During Smoking Cessation in Depressed Adults
A secondary analysis finds that behavioral activation therapy significantly lowers bodily pain scores compared to standard cessation care.
Randomized Controlled Trial
Intravascular Imaging Reduces Major Cardiac Events in Complex PCI
A randomized trial shows imaging guidance lowers the five-year risk of cardiac death and myocardial infarction in complex coronary lesions.
Randomized Controlled Trial
Middle Meningeal Artery Embolization Reduces Subdural Hematoma Recurrence
Adjunctive embolization after surgery lowered symptomatic recurrence from 28% to 4.3% in a randomized trial of 186 patients.
Randomized Controlled Trial
Digital and Primary Care Intervention Reduces Adolescent Depressive Symptoms in Slums
A randomized trial in India shows a multimedia campaign and digital tools improve mental health literacy and lower PHQ-9 scores.
Randomized Controlled Trial
IVUS Guidance Reduces Target Vessel Failure in Complex Bifurcation PCI
A randomized trial shows IVUS-guided optimization more than halves the 1-year risk of failure in complex double kissing crush procedures.
Non-Randomized Controlled Trial
Oral PCS499 Improves Skin Activity and Ulcer Healing in Necrobiosis Lipoidica
A phase 2 trial of a deuterated pentoxifylline analog shows 50% of patients achieved clear or almost clear status with no serious safety concerns.
Randomized Controlled Trial
2C-B Shows Empathogenic and Psychedelic Effects with Low Cardiovascular Strain
A crossover trial compares 30 mg of 2C-B to MDMA and psilocybin, finding similar emotional empathy and a shorter five-hour duration.
Randomized Controlled Trial
Interdisciplinary Whole Health Teams Improve Chronic Pain Function Over Standard Care
A randomized trial of 764 veterans shows that value-aligned team care reduces pain interference more than group therapy or usual care.
Randomized Controlled Trial
Semaglutide Improves Reward-Based Motivation in Patients With Major Depressive Disorder
A randomized trial shows oral semaglutide reduces the perceived cost of physical effort in patients with depression and elevated BMI.
Non-Randomized Controlled Trial
Cesium-131 Collagen Tiles Improve Local Control in Recurrent Meningioma
A phase 2 trial shows resection plus brachytherapy achieves 48% local control at five years for aggressive, recurrent meningiomas.
Non-Randomized Controlled Trial
Targeted sFlt-1 Apheresis Safely Extends Pregnancy in Very Preterm Preeclampsia
A pilot trial shows selective removal of sFlt-1 reduces maternal blood pressure and delays delivery by a median of 10 days.
Randomized Controlled Trial
Oral Factor D Inhibitor Fails to Improve Myasthenia Gravis Symptoms
A phase 2 trial of vemircopan was terminated after the oral complement inhibitor showed no significant benefit over placebo.
Randomized Controlled Trial
Pulsed Field Ablation Reduces Recurrence in Persistent Atrial Fibrillation
First-line pulsed field ablation showed a 56% success rate at 12 months compared to 30% for antiarrhythmic drugs in a randomized trial.
Non-Randomized Controlled Trial
Alternating Venetoclax Triplets Extend Survival in Older AML Patients
A phase 2 trial shows a 45% five-year survival rate and high rates of deep molecular remission using an alternating low-intensity regimen.
Randomized Controlled Trial
Mailed FIT-DNA Increases Colorectal Cancer Screening Rates in Community Health Centers
A pragmatic trial shows mailed FIT-DNA outreach achieves higher screening uptake than standard FIT, though follow-up colonoscopy rates remain low.
Randomized Controlled Trial
Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.