Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Randomized Controlled Trial
Online Therapist-Assisted Program Reduces Posttraumatic Stress in Injured Children
A randomized trial shows a digital cognitive behavioral intervention lowers symptom scores for six months following pediatric hospitalization.
Randomized Controlled Trial
Repeat OnabotulinumtoxinA for Masseter Prominence Does Not Alter Mandibular Bone
A 12-month placebo-controlled trial using CT imaging shows no significant bone remodeling after masseter injections for facial contouring.
Randomized Controlled Trial
Trabeculectomy Slows Visual Field Loss Better Than Medication in Advanced Glaucoma
A five-year trial shows surgery preserves monocular vision but finds no significant difference in patient-reported quality of life.
Randomized Controlled Trial
Symptom-Based Dosing Reduces Discharge Time in Neonatal Opioid Withdrawal
A cluster randomized trial shows symptom-based dosing shortens medical readiness for discharge when paired with the Eat, Sleep, Console model.
Randomized Controlled Trial
Proximal Nerve Stimulation Improves Sleep Apnea in CPAP-Intolerant Patients
A randomized trial shows proximal hypoglossal nerve stimulation significantly reduces apnea-hypopnea index and daytime sleepiness.
Randomized Controlled Trial
Luvadaxistat Fails to Improve Schizophrenia Cognition in Phase 2 Trial
The ERUDITE study found no significant cognitive benefit from adding the D-amino acid oxidase inhibitor to stable antipsychotic therapy.
Randomized Controlled Trial
Physical Therapy Improves Function More Than CBT in Chronic Low Back Pain
A sequential randomized trial finds physical therapy superior for initial functional gains, though secondary strategies show no difference.
Randomized Controlled Trial
Counterconditioning Stabilizes Neural Safety Signals in PTSD
Functional MRI shows pairing threat stimuli with positive outcomes reinforces safety patterns in the ventromedial prefrontal cortex.
Randomized Controlled Trial
Palliative Telecare Fails to Improve Goal Concordance in Cardiopulmonary Disease
A randomized trial of nurse and social worker-led phone interventions found no change in treatment alignment or patient uncertainty.
Randomized Controlled Trial
Specific RehaCom Modules Predict Processing Speed Gains in Progressive Multiple Sclerosis
Progression in attention-based modules and baseline characteristics like IQ and age determine cognitive outcomes in progressive MS.
Randomized Controlled Trial
NIRS-Guided Resuscitation Improves Early Motor Scores in Preterm Infants
A COSGOD III sub-study shows that monitoring cerebral oxygenation in the first 15 minutes of life correlates with better motor repertoire.
Randomized Controlled Trial
Balanced Fluids and Saline Show Similar Outcomes in Pediatric Septic Shock
A large trial of over 8,000 children found no difference in kidney events or mortality between balanced crystalloids and 0.9% saline.
Randomized Controlled Trial
Targeted Agents Fail to Extend Survival in Pediatric Brainstem Glioma
The BIOMEDE trial finds no survival benefit for erlotinib, dasatinib, or everolimus, but identifies TP53 as a key prognostic marker.
Non-Randomized Controlled Trial
Pitch Gestures Increase Prefrontal Activation During Mandarin Tone Sandhi Perception
Training with physical gestures strengthens functional connectivity in the left dorsolateral prefrontal cortex to improve auditory discrimination.
Randomized Controlled Trial
Triple-Pill Therapy Reduces Recurrent Stroke Risk After Intracerebral Hemorrhage
A low-dose combination of telmisartan, amlodipine, and indapamide lowered systolic blood pressure and major cardiovascular events.
Non-Randomized Controlled Trial
Phenylephrine Drops Match Eyelid Taping for Ptosis Insurance Qualification
A comparative study shows phenylephrine 2.5% achieves similar visual field gains as taping with significantly higher patient satisfaction.
Randomized Controlled Trial
Brolucizumab Preserves Vision Better Than Laser in Diabetic Retinopathy
The Phase 3 CONDOR trial shows brolucizumab 6 mg maintains visual acuity and regresses disease more effectively than panretinal laser.
Randomized Controlled Trial
Left Bundle Branch Pacing Reduces Cardiomyopathy Risk in High-Burden Patients
A randomized trial shows left bundle branch pacing lowers composite clinical events and improves ventricular function over 36 months.
Non-Randomized Controlled Trial
Dupilumab Resolves Airway Mucus Plugs and Reduces Radiodensity in Asthma
A longitudinal CT analysis shows dupilumab clears 91% of existing mucus plugs and alters the physical composition of remaining obstructions.
Non-Randomized Controlled Trial
Donor-Derived Anti-CD33 CAR T-Cells Show Safety in Relapsed AML Post-Transplant
A phase 1/2 trial of VCAR33 demonstrates manageable toxicity and preliminary activity in patients with relapsed or MRD-positive disease.
Randomized Controlled Trial
Baricitinib Noninferior to Etanercept for Reducing Ultrasound-Assessed Synovitis
A phase IV trial shows baricitinib, with or without methotrexate, matches etanercept in objective measures of joint inflammation.
Randomized Controlled Trial
Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.
Non-Randomized Controlled Trial
Vuzix Head-Mounted Device Scores Highest in Prehospital Stroke Triage Simulation
A comparative study finds neurologists prefer head-mounted video quality while paramedics favor smartphone usability for remote triage.
Randomized Controlled Trial
Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
Randomized Controlled Trial
Focal Coronary Disease Predicts Greater Angina Relief After Stenting
New ORBITA-2 data show focal lesions derive significantly more placebo-controlled benefit from PCI than diffuse disease patterns.
Randomized Controlled Trial
LB-102 Reduces Acute Schizophrenia Symptoms in Phase 2 Trial
A randomized trial of the benzamide derivative LB-102 demonstrated significant PANSS score improvements across three daily dose levels.
Randomized Controlled Trial
Nirmatrelvir-Ritonavir Fails to Reduce Hospitalization in Vaccinated Outpatients
Two randomized trials show no significant clinical benefit for high-risk adults with prior immunity from vaccination or infection.
Randomized Controlled Trial
Early Enteral Nutrition Reduces Complication Burden After Pancreatoduodenectomy
A randomized trial shows immediate tube feeding lowers the comprehensive complication index in patients at high nutritional risk.
Randomized Controlled Trial
Funnel-Shaped Mesh Reduces Parastomal Hernia Risk After Rectal Cancer Surgery
A randomized trial shows prophylactic mesh lowers three-year clinical hernia rates from 39% to 10% without increasing complications.
Non-Randomized Controlled Trial
Telepractice PTR-F Improves Parent Fidelity in Chinese American Families
A culturally adapted behavioral intervention delivered remotely increased parent adherence and reduced challenging behaviors in autistic children.