Trial Watch
Clinical trials covered by The Clinical Lighthouse, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Randomized Controlled Trial
Tucidinostat Improves Event-Free Survival in Double-Expressor B-Cell Lymphoma
Adding a histone deacetylase inhibitor to R-CHOP increases complete response rates and reduces progression risk in high-risk patients.
Randomized Controlled Trial
Dialectical Behavior Therapy and Schema Therapy Show Similar Efficacy for BPD
A 3-year randomized trial found no significant difference in symptom reduction or dropout between these two intensive psychotherapies.
Randomized Controlled Trial
Tranexamic Acid Reduces Major Bleeding in Urologic Surgery
A randomized trial of 1,124 patients shows TXA reduces major bleeding by 3.4% without significantly increasing 30-day thrombotic risk.
Randomized Controlled Trial
Behavioral Nursing Model Improves Glycemic Control and Cognition in Older Diabetes Patients
A three-month Information-Motivation-Behavioral Skills intervention reduced HbA1c and psychological distress while improving cognitive scores.
Randomized Controlled Trial
Estradiol Patches Noninferior to LHRH Agonists in Prostate Cancer
A phase 3 trial shows transdermal estradiol maintains metastasis-free survival while reducing hot flashes in locally advanced disease.
Randomized Controlled Trial
Participation-Focused Training Improves Immediate Post-Stroke Executive Function in Randomized Trial
Strategy training shows short-term cognitive gains in stroke survivors, though benefits do not persist at three-month follow-up.
Non-Randomized Controlled Trial
Immune-Guided Strategy Reduces CMV Disease in Kidney Transplant Recipients
Early assessment of cell-mediated immunity allows for targeted prophylaxis, lowering symptomatic disease rates in seropositive patients.
Randomized Controlled Trial
Improved House Design Reduces Malaria and Respiratory Infections in Children
A cluster-randomized trial in rural Africa shows that Star Homes lower malaria incidence by 44% and improve linear growth in children.
Randomized Controlled Trial
Immersive Virtual Reality Improves Naming in Chronic Non-Fluent Aphasia
A randomized trial shows immersive therapy yields higher gains in oral motor function and patient enjoyment than conventional methods.
Randomized Controlled Trial
Memantine Reduces Premature Atrial Contractions and New-Onset Atrial Fibrillation
A phase 2 trial shows targeting cardiac N-methyl-D-aspartate receptors significantly lowers atrial ectopy and tachyarrhythmia burden.
Randomized Controlled Trial
Adding Tobramycin to Vancomycin Powder Does Not Reduce Tibial Fracture Infections
A randomized trial of 1528 patients shows dual intrawound antibiotic powder offers no benefit over vancomycin alone in high-risk fractures.
Randomized Controlled Trial
Eccentric Cycling Matches Concentric Training for Post-COVID-19 Walking Recovery
An 8-week trial shows eccentric cycling is safe and improves walking distance, though it offers no advantage over concentric exercise.
Non-Randomized Controlled Trial
Mosunetuzumab and Polatuzumab Vedotin Show High Response in Refractory MCL
A phase 2 trial reports a 78.6% complete response rate in patients with mantle cell lymphoma after Bruton tyrosine kinase inhibitor failure.
Randomized Controlled Trial
Baseline Connectivity Predicts Anxiety Improvement in Prefrontal TMS Trial
Pre-treatment neural architecture, rather than post-stimulation connectivity changes, correlates with clinical recovery in patients.
Randomized Controlled Trial
Seven-Day Low-Plastic Intervention Lowers Urinary Phthalates and Bisphenol A
A randomized trial shows that minimizing plastic contact in food and personal care reduces endocrine disruptors linked to metabolic risk.
Randomized Controlled Trial
Thrombectomy Increases Tissue Salvage in Distal Vessel Occlusion Stroke
A post hoc analysis of the DISTAL trial shows endovascular therapy preserves more at-risk brain tissue than medical management alone.
Non-Randomized Controlled Trial
Cibisatamab and FAP-4-1BBL Show Activity in Refractory Colorectal Cancer
A phase 1b trial finds that combining a CEA-targeted bispecific antibody with localized 4-1BB co-stimulation induces objective responses.
Randomized Controlled Trial
Telehealth Integration Does Not Prevent Quality of Life Decline in Palliative Care
A randomized trial of 182 patients found no significant differences in symptom burden or security between telehealth and standard care.
Non-Randomized Controlled Trial
Large Language Models Reduce Radiology Reporting Time and Transcription Errors
A multicenter study finds LLMs faster than conventional speech recognition but notes inconsistent efficiency and new error types.
Non-Randomized Controlled Trial
Cilta-cel Induces Universal MRD Negativity in High-Risk Smoldering Multiple Myeloma
A phase 2 trial shows 100% of patients achieved deep, sustained responses without prior induction therapy or disease progression.
Randomized Controlled Trial
Cerebral Oximetry Fails to Improve 2-Year Outcomes in Preterm Infants
A phase 3 trial of 1,601 infants shows no reduction in death or disability when using oximetry to guide early postnatal care.
Randomized Controlled Trial
Routine Dementia Screening Shows No Benefit or Harm for Family Members
A randomized trial finds cognitive screening in primary care does not impact family quality of life, preparedness, or psychological distress.
Randomized Controlled Trial
Amoxicillin Equals Amoxicillin-Clavulanate for Acute Sinusitis
A nationwide cohort study shows standard amoxicillin is as effective as amoxicillin-clavulanate but avoids higher risks of C. difficile.
Randomized Controlled Trial
Serious Games Reduce Geriatric Trauma Undertriage in Nontrauma Centers
A randomized trial of 800 emergency physicians shows digital simulation training improves adherence to triage guidelines for older adults.
Non-Randomized Controlled Trial
Risk-Adapted Therapy Improves Survival in Pediatric Acute Myeloid Leukemia
Refined stratification using measurable residual disease and genetics increased 3-year overall survival to 83.9% in a large cohort.
Randomized Controlled Trial
Endovascular Therapy Eases Post-Thrombotic Syndrome but Increases Bleeding
Iliac-vein stenting with enhanced antithrombotics improves symptoms and quality of life at six months, despite a higher bleeding risk.
Randomized Controlled Trial
Routine Prednisolone Does Not Prevent Coronary Lesions in Kawasaki Disease
A large randomized trial shows that adding steroids to standard therapy does not protect the coronary arteries of unselected children.
Randomized Controlled Trial
Zongertinib Drives High Response in First-Line HER2-Mutant Lung Cancer
The selective HER2 inhibitor achieved a 76% objective response rate and durable progression-free survival in treatment-naive patients.
Randomized Controlled Trial
Coping and Self-Efficacy Mediate Mood Improvements in Brain Tumor Caregivers
A secondary analysis of a randomized trial shows that a telehealth intervention reduces anxiety and depression by targeting specific psychological mec
Randomized Controlled Trial
Fecal Transplant Fails to Decolonize Resistant Bacteria in GI Disease
A randomized trial shows single-dose fecal microbiota transplant does not reduce multidrug-resistant organisms or resistance genes.