The Briefing · Emergency & Critical Care
Continuous newsroom coverage of evidence in Emergency & Critical Care — newest first.
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Higher Rocuronium Dose Linked to Increased First-Attempt Intubation Success in ICU
A secondary analysis suggests that rocuronium doses above 1.2 mg/kg improve intubation success in critically ill ICU patients.
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Idarucizumab Reversal Before Thrombolysis in AIS Patients Shows Comparable Safety
Real-world data suggest intravenous thrombolysis after dabigatran reversal is safe and effective as in non-anticoagulated patients.
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ABCDEF Bundle Does Not Reduce Delirium, Improves Specific Quality of Life Domain
A randomized trial in Australian ICU patients found no delirium reduction with the ABCDEF bundle, but noted better 90-day 'usual activities' scores.
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Protein-Based Model Improves Short-Term Lung Cancer Risk Prediction
A new protein-based model enhances identification of individuals with a smoking history at high short-term risk for lung cancer.
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Postpartum Period Linked to Higher Risk of Myasthenia Gravis Exacerbations
A population-based cohort study clarifies the fluctuating risk of myasthenia gravis exacerbations during and after pregnancy.
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Multimodal Prehabilitation Reduces Complications, Shortens Hospital Stays After Colorectal Surgery
A nationwide cohort study shows pre-surgical interventions improve outcomes for unselected colorectal cancer patients.
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ARDS Inflammatory Phenotypes Show Differential Mortality and Ventilation Response
A retrospective cohort study reveals distinct 60-day mortality rates and varied responses to lung-protective ventilation parameters across ARDS.
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Texas Abortion Ban Linked to Increased Critical Illness in High-Risk Pregnant Patients
A retrospective cohort study in Texas found that a 2021 abortion ban correlated with higher rates of critical illness, sepsis, and infection.
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Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
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Acute Care Surgery Fellowships Accelerate Military Surgical Readiness
A retrospective analysis indicates that AAST ACS fellowships enable general surgeons to meet military readiness standards within 12 months.
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COPD Bronchoalveolar Lavage Reveals Specific Immune Cell Shifts Linked to Disease Severity
Single-cell sequencing identifies expanded macrophage, monocyte, and T-lymphocyte populations associated with airflow limitation and gas exchange.
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MIPD Improves Early Postoperative Activity, Reduces Stress for Pancreatic Resection
A randomized trial shows minimally invasive pancreatoduodenectomy leads to higher physical activity and heart rate variability for weeks.
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Weight Loss Intervention Safe in Older AF Patients, But Does Not Improve Symptoms
A randomized clinical trial indicates that while weight loss is achievable and safe in older, overweight AF patients, it may not reduce AF symptoms.
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Azithromycin Does Not Reduce Acute Wheezing Severity in Preschoolers
A multicenter trial found azithromycin offered no significant clinical benefit over placebo for moderate-to-severe wheezing symptoms.
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Vertebrobasilar and Middle Cerebral Aneurysms Carry Highest Case Fatality Rates
A population-based study of 13,470 cases shows that aneurysm location significantly influences sudden death and 30-day mortality risks.
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Inhaled Treprostinil Slows Lung Function Decline, Reduces Clinical Worsening in IPF
A phase 3 trial demonstrates that inhaled treprostinil significantly mitigates FVC reduction and clinical deterioration in patients with idiopathic.
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Validating Generative AI Therapeutics: A Proposed Framework for Clinical Integration
A new framework outlines a multi-stage validation process to ensure the safety and efficacy of generative AI agents in mental health care.
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Fine Particulate Matter Increases Risk of Recurrent Stroke and Death
A national cohort study finds that PM2.5 exposure nearly triples the risk of stroke recurrence and secondary cardiovascular events.
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4% Tetrasodium EDTA Lock Reduces CVAD Complications in ICU Adults
A multicenter, cluster-randomized trial shows 4% t-EDTA locking fluid decreases a composite of CVAD-associated events, primarily catheter occlusions.
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VSED with Hospice: Clinical Course, Symptom Management, and Patient Demographics
A case series details the clinical trajectory, symptom burden, and care needs of patients choosing voluntarily stopping eating and drinking.
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Tezepelumab Reduces Oral Corticosteroid Use in Severe Asthma
A phase 3 trial demonstrates that tezepelumab significantly lowers daily oral corticosteroid dose in adults with severe, OCS-dependent asthma.
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Dupilumab Reduces COPD Hospitalizations, ED Visits, and Corticosteroid Use
A pooled analysis of two phase 3 trials shows dupilumab significantly lowers healthcare utilization and corticosteroid burden in COPD patients.
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Selective Early PDA Pharmacotherapy Feasible in Extremely Preterm Infants
A pilot randomized trial demonstrates the feasibility of a targeted medical approach for patent ductus arteriosus in infants under 26 weeks'.
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Non-Ischemic Dilated Cardiomyopathy: Higher Prevalence, Complex Genetics
Updated estimates suggest non-ischemic dilated cardiomyopathy affects 1 in 220, driven by diverse genetic and environmental factors.