Trial Watch · Emergency & Critical Care
Clinical trials in Emergency & Critical Care, ranked by methodological rigor and ordered by most recent.
Prehospital Whole Blood Does Not Reduce 30-Day Mortality Over Components
A large-scale trial found no significant difference in 30-day mortality between prehospital whole blood and component transfusions for trauma.
Randomized Controlled Trial
Bispecific CAR T-Cells Show High Response in Extramedullary Multiple Myeloma
A phase 2 trial reports high overall response and manageable safety with anti-BCMA/GPRC5D CAR T-cells for relapsed/refractory disease.
Randomized Controlled Trial
CBD's Pain Modulation Effects Vary by Opioid Dosing Timing in OUD Patients
A crossover study reveals cannabidiol's impact on pain sensitivity is dependent on whether opioid agonist treatment has been administered.
Non-Randomized Controlled Trial
Venetoclax Plus Chemotherapy Improves MRD Response, Survival in Ph-Negative ALL
A phase 2 study shows venetoclax combined with pediatric-inspired chemotherapy enhances outcomes for newly diagnosed adolescents and adults.
Randomized Controlled Trial
ABCDEF Bundle Does Not Reduce Delirium, Improves Specific Quality of Life Domain
A randomized trial in Australian ICU patients found no delirium reduction with the ABCDEF bundle, but noted better 90-day 'usual activities' scores.
Randomized Controlled Trial
Low-Dose Buprenorphine Sustains Ketamine's Antisuicidal Effects in MDD
A randomized trial indicates sublingual buprenorphine extends ketamine's rapid reduction of suicidal ideation in major depressive disorder.
Randomized Controlled Trial
MIPD Improves Early Postoperative Activity, Reduces Stress for Pancreatic Resection
A randomized trial shows minimally invasive pancreatoduodenectomy leads to higher physical activity and heart rate variability for weeks.
Randomized Controlled Trial
Azithromycin Does Not Reduce Acute Wheezing Severity in Preschoolers
A multicenter trial found azithromycin offered no significant clinical benefit over placebo for moderate-to-severe wheezing symptoms.
Randomized Controlled Trial
Weight Loss Intervention Safe in Older AF Patients, But Does Not Improve Symptoms
A randomized clinical trial indicates that while weight loss is achievable and safe in older, overweight AF patients, it may not reduce AF symptoms.
Randomized Controlled Trial
Inhaled Treprostinil Slows Lung Function Decline, Reduces Clinical Worsening in IPF
A phase 3 trial demonstrates that inhaled treprostinil significantly mitigates FVC reduction and clinical deterioration in patients with idiopathic.
Randomized Controlled Trial
4% Tetrasodium EDTA Lock Reduces CVAD Complications in ICU Adults
A multicenter, cluster-randomized trial shows 4% t-EDTA locking fluid decreases a composite of CVAD-associated events, primarily catheter occlusions.
Randomized Controlled Trial
Tezepelumab Reduces Oral Corticosteroid Use in Severe Asthma
A phase 3 trial demonstrates that tezepelumab significantly lowers daily oral corticosteroid dose in adults with severe, OCS-dependent asthma.
Randomized Controlled Trial
Selective Early PDA Pharmacotherapy Feasible in Extremely Preterm Infants
A pilot randomized trial demonstrates the feasibility of a targeted medical approach for patent ductus arteriosus in infants under 26 weeks'.
Randomized Controlled Trial
Remote Multicomponent Rehabilitation Does Not Improve Quality of Life for ICU Survivors
A randomized trial found a 6-week remote rehabilitation program did not significantly enhance health-related quality of life at 8 weeks.
Randomized Controlled Trial
AD109 Reduces Apnea-Hypopnea Index in PAP-Intolerant OSA Patients
An oral combination of aroxybutynin and atomoxetine significantly improved objective respiratory metrics over 26 weeks.
Randomized Controlled Trial
Astegolimab Reduces COPD Exacerbations in Broad Patient Population
A pooled analysis of two trials shows astegolimab significantly lowers moderate/severe exacerbation rates in patients with frequent COPD.
Randomized Controlled Trial
Armchair Positioning Improves Oxygenation in Spontaneously Breathing ICU Patients
A randomized controlled trial found out-of-bed armchair positioning increased PaO2/FiO2 ratios compared to in-bed semi-recumbent positioning.
Randomized Controlled Trial
Digital Decision Aid Boosts STI Testing in ED for Young Adults
A randomized trial shows a smartphone-based tool significantly increases gonorrhea/chlamydia and pharyngeal STI testing rates in emergency department
Randomized Controlled Trial
Anti-C5a Antibody STSA-1002 Shows Favorable Safety, Reduced Mortality in ARDS
A phase 1b/2 trial indicates STSA-1002 is well tolerated and associated with lower 28-day mortality in viral pneumonia-induced ARDS.
Non-Randomized Controlled Trial
ED Nudge Strategy Increases Naltrexone Prescribing for Alcohol Misuse
A multicomponent emergency department protocol significantly raised naltrexone initiation for patients with alcohol-related diagnoses.
Randomized Controlled Trial
Favipiravir Safe, Well-Tolerated for Mild-to-Moderate Lassa Fever
A phase 2 trial in Nigeria provides pharmacokinetic data and supports favipiravir as an alternative to ribavirin for Lassa fever.
Randomized Controlled Trial
Thrombectomy Improves Functional Independence in Medium-Vessel Occlusion Stroke
A randomized trial shows endovascular thrombectomy increases functional independence but also raises symptomatic intracranial hemorrhage risk in mediu
Randomized Controlled Trial
Intravenous Magnesium Sulfate Reduces Rescue Analgesia for Acute Headache
A randomized trial finds adjunctive magnesium sulfate increases treatment success and patient satisfaction, despite pain reduction not meeting clinica
Randomized Controlled Trial
Daratumumab-VCd Improves Survival, Organ Function in AL Amyloidosis
Final ANDROMEDA analysis confirms sustained benefits of D-VCd for newly diagnosed light-chain amyloidosis, including overall survival.
Randomized Controlled Trial
Ensitrelvir Reduces COVID-19 Incidence by 6.1% in Household Contacts
An oral SARS-CoV-2 3C-like protease inhibitor significantly lowers infection rates when given as postexposure prophylaxis.
Randomized Controlled Trial
Sutureless Robotic Partial Nephrectomy Noninferior to Renorrhaphy for Renal Tumors
A randomized controlled trial indicates sutureless off-clamp robotic partial nephrectomy offers comparable surgical quality for cT1-2N0M0 renal tumors
Randomized Controlled Trial
Telitacicept Reduces Proteinuria in IgA Nephropathy: Phase 3 Interim Analysis
A dual BAFF and APRIL antagonist significantly lowers urinary protein-to-creatinine ratio in adults with IgA nephropathy at high risk of progression.
Randomized Controlled Trial
Patient-Level Adherence Drives Enhanced Recovery Benefits in Pediatric GI Surgery
A stepped-wedge trial shows that while site-level ERP implementation may not reduce length of stay, patient-level adherence does.
Randomized Controlled Trial
Lower Oxygen Saturation Target Reduces Pediatric Hospital Stay, Oxygen Therapy
A multicenter trial suggests targeting 88% peripheral oxygen saturation in children with acute respiratory illness shortens hospitalizations.
Randomized Controlled Trial
Intra-Arterial Alteplase Improves Recovery After Successful Thrombectomy
Adjunctive thrombolysis increased 90-day functional independence by 15% but was associated with a nearly 6% increase in mortality.