The Briefing · Psychiatry & Cognitive Neurology
Continuous newsroom coverage of evidence in Psychiatry & Cognitive Neurology — newest first.
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GABAergic Signaling and SST Interneurons Boost Dendritic Calcium Influx
A new study in mice reveals how specific GABA-A receptors and somatostatin-expressing interneurons can paradoxically enhance neuronal calcium signalin
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Parkinson's Dementia Risk Lower, Later Than Prior Estimates
New data from the Parkinson's Progression Markers Initiative refines understanding of cognitive decline prevalence and progression.
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Macaque V1 Neuron Activity Links Internal States to Reaction Time, Perceptual Choice
New research in macaque monkeys reveals how primary visual cortex neuron membrane potential dynamically influences visual task performance.
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Familial Brain Pattern Similarity Links to Psychotic Disorder Risk in Offspring
A new index quantifying cortical thickness similarity between parents with psychosis and their offspring correlates with psychiatric diagnoses.
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Acute Kidney Injury Predicts Increased Risk of Stroke and Dementia
A meta-analysis of 11 million patients links acute renal insults to a 35% higher stroke risk and nearly fivefold 90-day poststroke mortality.
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Intracranial Recordings Map Immediate and Distal Neural Responses to Magnetic Stimulation
A review of human and primate data shows single-pulse TMS excites neurons in 2 milliseconds and modulates networks for up to 40 minutes.
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Digital Interventions Improve Eating Disorder Symptoms and Comorbid Mental Health
A meta-analysis of 36 trials shows digital tools offer consistent, durable benefits for core eating disorder symptoms and associated mental health con
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Memory Deficits Persist in Multiple Sclerosis Despite Preserved Processing Speed
Modern treatment eras show a shift where cognitive slowing is no longer the primary deficit in relapsing-remitting multiple sclerosis.
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Current Late-Life Depression Linked to Specific Right Hippocampal Subregion Volume Reductions
A new study details distinct hippocampal volume alterations in currently depressed older adults, differentiating them from remitted states.
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REM Sleep EEG Slowing Linked to Cholinergic Denervation in Older Adults
Specific REM sleep electroencephalogram patterns correlate with brain cholinergic integrity, potentially aiding early diagnosis in Alzheimer's disease
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Maternal Fasting in Mice Induces Schizophrenia-Related Phenotypes
A mouse model links transient fasting during early gestation to epigenetic changes and altered neural circuitry in offspring.
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Focal Brain Lesions Pinpoint Common OCD Network and Treatment Targets
A systematic review identifies a shared brain network in lesional and primary OCD, aligning with neuroimaging and neuromodulation sites.
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Habenula Hyperconnectivity in Autism Linked to Social Deficits
A large-scale rs-fMRI study identifies specific habenula functional connectivity alterations in autistic individuals, impacting social motivation.
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Age, Sex, and Initial Diagnosis Shape Mental Disorder Trajectories
A large Danish cohort study details how initial diagnosis, age, and sex influence diagnostic shifts and healthcare utilization.
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FDA-Approved Therapies and Multidisciplinary Care Extend Survival in ALS
New clinical data highlight the role of genetic testing and targeted therapies in managing progressive motor neuron degeneration.
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FGF14 Repeat Expansions Identified in Patients with Parkinson's Disease
Long-read sequencing reveals that a genetic variant linked to ataxia also occurs in patients meeting clinical criteria for Parkinson's.
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Cerebrotendinous Xanthomatosis Drives Recurrent Stroke After PFO Closure
A 23-year-old's recurrent M1 occlusion reveals how metabolic drivers of premature atherosclerosis can mimic or coexist with structural defects.
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Accelerated Deep TMS Protocols Show High Remission Rates in Depression
A randomized trial finds that 10-day accelerated deep TMS protocols achieve 42% to 50% remission rates, exceeding pharmacotherapy alone.
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Testosterone Therapy Improves Sexual Function After Radical Prostatectomy
A phase 2 trial shows 12 weeks of testosterone cypionate enhances libido and body composition without triggering biochemical recurrence.
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Children Witness Nearly Ten Percent of US Violent Deaths and Suicides
A CDC surveillance analysis reveals that most child-witnessed fatal events occur in homes and involve firearms or domestic conflict.
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Genetic Risk and Social Deprivation Drive Regional Drug Use Clusters
A Swedish study of 5,983 districts finds that family genetic risk and community deprivation explain most geographic variation in addiction.
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Reduced Visit Pressure Increases Diagnosis Rates in Primary Care
A study of 191,269 visits shows that relieving schedule constraints allows physicians to address more new and chronic clinical issues.
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Galectin-3 Inhibition Prevents Excitatory Synapse Loss in Murine Neuroinflammation Models
Targeting microglial Galectin-3 preserves hippocampal gamma power and cognitive function by stopping the selective engulfment of synapses.
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Redlining and Modern Loan Denials Drive Chicago Firearm Homicides
Historical housing maps and current economic discrimination act as independent, measurable factors in urban firearm violence disparities.