The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
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Cardiac Arrest Increases Mortality and Coronary Complexity in STEMI Shock
A retrospective study of 345 patients shows that cardiac arrest in cardiogenic shock signals higher SYNTAX scores and 80% 1-year mortality.
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Four Distinct Internet Addiction Profiles Identified in Nursing Students
Latent profile analysis reveals that health-related problems and withdrawal symptoms drive severity in high-risk student groups.
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Prior Tibial Osteotomy Increases Revision Risk After Conversion Knee Arthroplasty
A national database study finds higher rates of stiffness and revision in younger patients transitioning from osteotomy to total knee replacement.
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Hospital and Surgeon Culture Drive Extended-Release Opioid Use After Arthroplasty
A study of 229,995 joint replacements shows institutional patterns, not patient factors, primarily dictate postoperative long-acting opioid dispensing
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Physician-Led Program Improves Prehospital Care for Medically Complex Children
The STARS initiative uses individualized electronic care plans and targeted EMS training to reduce unnecessary hospital transports.
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Childhood Trauma Linked to Altered Mitochondrial Bioenergetics in Adults
Adults with early life adversity show increased mitochondrial respiratory capacity and reduced glycolytic ATP production in immune cells.
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Donor-Derived Anti-CD33 CAR T-Cells Show Safety in Relapsed AML Post-Transplant
A phase 1/2 trial of VCAR33 demonstrates manageable toxicity and preliminary activity in patients with relapsed or MRD-positive disease.
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Preoperative Antifibrinolytics Reduce Transfusions After Vascular Surgery
A multi-hospital study finds early administration of tranexamic acid or epsilon-aminocaproic acid lowers transfusion needs by 43 percent.
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Creative Adolescents Show Higher Neural Synchrony During Complex Film Viewing
Functional MRI data reveal that highly creative youth exhibit unique attentional alignment when processing non-linear cinematic montage.
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Training-Free AI Framework Automates Radiographic Morphometry Across Multiple Joints
A generalist landmark matching model achieves measurement accuracy comparable to radiologists without requiring anatomy-specific datasets.
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Early Thrombectomy Reduces Intubation in Intermediate-Risk Pulmonary Embolism
Intervention within 12 hours improves hemodynamic recovery and lowers ventilation risk despite similar mortality to delayed procedures.
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ME/CFS Linked to Reduced Bioactive Cortisol and Heightened Feedback Sensitivity
A meta-analysis of 46 studies confirms a neuroendocrine signature of low cortisol and HPA-axis hyporeactivity in chronic fatigue patients.
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DSDO Lenses Reduce Axial Elongation More Than DIMS in Myopic Children
A multicenter study of 1,541 participants shows DSDO lenses also suppress physiological eye growth in non-myopic children over 12 months.
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Liver Stiffness Better Reflects Cumulative Hepatic Injury Than Iron Concentration in Thalassemia
Elastography identifies advanced fibrosis in transfusion-dependent patients even when iron levels are well-controlled by chelation therapy.
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Low-Burden COPD Exacerbations Predict Future Respiratory Events
Even home-managed symptoms or a single moderate event correlate with structural lung damage and increased risk of future crises.
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Neural Responses to Reward Uncertainty Linked to Adolescent Anxiety and Anhedonia
Striatal and default network activity during uncertain reward tasks correlates with symptom severity in medication-free adolescents.
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Baricitinib Noninferior to Etanercept for Reducing Ultrasound-Assessed Synovitis
A phase IV trial shows baricitinib, with or without methotrexate, matches etanercept in objective measures of joint inflammation.
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Quantiferon-CMV Guided Prophylaxis Fails to Lower Infection in Seropositive Kidney Recipients
Early post-transplant immune monitoring did not reduce infection rates compared to standard preemptive therapy in low-risk patients.
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Kratom Leaf Extract Alleviates Stress-Induced Bladder Dysfunction in Male Mice
Oral mitragynine reduces bladder pain, mast cell infiltration, and muscarinic hyperreactivity in a murine model of chronic stress.
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Oral Dysbiosis Linked to Systemic Inflammation and Autism Symptoms
Review identifies enrichment of Porphyromonas and Tannerella as potential drivers of neurodevelopmental patterns via the oral-brain axis.
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Guillain-Barré Syndrome Incidence Declined 9% in Japan During the Pandemic
A nationwide survey reveals a shift toward demyelinating subtypes and older patients as conventional infectious triggers decreased.
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Telehealth and In-Person Lung Cancer Screening Consultations Show Equivalent Quality
A study of Veterans Affairs patients found no significant difference in shared decision-making quality or scan adherence between modalities.
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![[89Zr]girentuximab PET Identifies Any Renal Malignancy with 98% Positive Predictive Value](/images/thumb/384/89zrgirentuximab-pet-identifies-any-renal-malignan-April-01-2026.jpg)
[89Zr]girentuximab PET Identifies Any Renal Malignancy with 98% Positive Predictive Value
A secondary analysis of the ZIRCON trial indicates the CAIX-targeted tracer detects non-clear cell subtypes with high clinical accuracy.
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Remote Ischaemic Preconditioning Fails to Prevent Postoperative Myocardial Injury
A randomized trial of two-session preconditioning in abdominal surgery shows no reduction in injury and a paradoxical troponin increase.