The Briefing
Continuous newsroom coverage of clinically relevant evidence — newest first.
Earlier
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Oncology Providers Prioritize Social Support and Symptom Control at End-of-Life
A qualitative study of 49 clinicians reveals how personal values differ by career stage and may influence patient-centered care.
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One in Three ICH Patients on Antithrombotics Lack Clinical Indication
A retrospective study finds 30.4% of patients with intracranial hemorrhage were taking unindicated anticoagulants or antiplatelets.
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African Populations Underrepresented in High-Impact Clinical Trials
A systematic review of 2,472 trials shows that only 0.6% of cardiovascular studies were conducted exclusively in Africa.
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Metacognitive Beliefs Condition the Link Between Somatic Symptoms and Health Anxiety
A survey of 564 adults shows anxiety sensitivity only amplifies health anxiety when patients hold high beliefs about their biased thinking.
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Emotional Trauma Drives Adolescent Alexithymia Through Gender-Specific Pathways
Network analysis of 2,447 adolescents identifies emotional abuse and neglect as primary drivers of specific emotional processing deficits.
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Injectable Antipsychotics Reduce Hospitalization and Relapse in Bipolar Disorder
A mirror-image study shows paliperidone and aripiprazole long-acting formulations significantly lower psychiatric service use and relapse.
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Daily Resistance Training and Verticalization Safe During ECMO Support
A pilot study shows that structured mobility and resistance exercises correlate with improved functional performance in critically ill adults.
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Stroke Etiology Does Not Alter Bridging Thrombolysis Efficacy
A meta-analysis of six trials finds no interaction between stroke cause and the benefit of thrombolysis before mechanical thrombectomy.
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Specific Combination Therapies Reduce Hospitalization Risk After Lithium Failure
A large cohort study identifies clozapine and long-acting injectable combinations as effective alternatives for maintenance treatment.
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Plasma Heme Assay Predicts Mortality Risk in Sickle Cell Disease
Direct quantification of heme species identifies patients with severe hemolysis and exhausted scavenging capacity better than indirect markers.
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Network Connectivity Drives Individual Variation in Emotional Memory
Large-scale fMRI study finds distributed neural networks, not isolated amygdala activity, predict how emotional arousal enhances recall.
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Endovascular Stent-Graft Repairs Iatrogenic Subclavian Vein Injury
A 60-year-old patient maintains vessel patency two years after emergency endovascular treatment for a life-threatening venous perforation.
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Vuzix Head-Mounted Device Scores Highest in Prehospital Stroke Triage Simulation
A comparative study finds neurologists prefer head-mounted video quality while paramedics favor smartphone usability for remote triage.
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Adolescent Opioid Harms Double Despite Reduced Emergency Department Prescribing
A decade-long study of 1.2 million visits shows that cutting pediatric opioid prescriptions did not prevent a rise in clinical harms.
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Pyramidal Cell Hypofunction Predicts Psychosis Conversion in High Risk Patients
Biophysical modeling of auditory biomarkers suggests that excitatory deficits, not interneuron dysfunction, drive the transition to psychosis.
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Most Validated Radiomics Models Lack Sufficient Training Data
A systematic review of high-impact journals finds 90% of machine learning models are undertrained, risking unreliable clinical predictions.
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Periarticular Injection Reduces Opioid Use After Knee Infection Surgery
A retrospective study of 309 patients shows local anesthetic infiltration lowers pain scores without increasing 12-month reinfection risk.
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Structured Exercise and Resistance Training Safe During ECMO Support
A pilot study of 20 patients shows that intensive twice-daily rehabilitation correlates with improved functional performance and survival.
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SIRT5 Deficiency Drives Cardiac Fibrosis via Metabolic Shift in Mice
Loss of SIRT5 in cardiac fibroblasts triggers a glycolytic shift that accelerates heart failure, identifying a potential metabolic target.
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Early Dopamine Loss Drives Memory Deficits in Alzheimer's Mouse Model
Dysfunction in dopamine neurons projecting to the lateral entorhinal cortex precedes neurodegeneration and impairs associative memory.
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Inconsistent ALS Trial Analytics Increase False Positive Risk
A review of 45 trials shows that statistical method choice can swing treatment effect estimates and risk advancing ineffective therapies.
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For-Profit Trauma Centers Increase Redundancy but Fill Critical Access Gaps
Geospatial analysis shows for-profit centers serve 43 million people, often overlapping with existing nonprofit trauma infrastructure.
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Ketamine Does Not Reduce 28-Day Mortality Compared With Etomidate
A randomized trial of 2,365 critically ill adults found no survival benefit for ketamine, despite a higher rate of cardiovascular collapse.
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Sleep Apnea Prevalence Reaches 69% in Former Professional Football Players
Undiagnosed and untreated sleep apnea significantly correlate with increased pain, anxiety, and cognitive impairment in former athletes.