Four Months of Fingolimod Does Not Improve Anxiety or Depression in MS
A prospective study of 61 patients with relapsing-remitting MS found no significant changes in mood scores after initiating fingolimod.
MRI Tracks Hippocampal Damage and Recovery in Rat Epilepsy Model
A longitudinal study in rats reveals acute hippocampal volume loss after status epilepticus, followed by partial recovery over 30 days.
Menstrual Cycle Phases Alter Brain Reactivity to Drug Cues
Functional MRI reveals that estrogen heightens cue-induced craving in women with substance use disorders, while progesterone blunts it.
Alexithymia and Poor Coping Link Trauma to Self-Injury in Depressed Youth
An inability to process emotions drives maladaptive coping, forming a chain reaction that connects early trauma to adolescent self-harm.
Early Famine Exposure Linked to Accelerated Functional Decline in Older Adults
Nutritional deprivation during fetal and preschool development increases the risk of rapid intrinsic capacity deterioration by over 50 percent.
Peri-Ictal MRI Abnormalities Predict 60% Seizure Risk After Status Epilepticus
Transient DWI and FLAIR changes within 48 hours of a first status epilepticus episode identify patients at high risk for epilepsy.
Inhaled Methoxyflurane Avoids IV Sedation in Half of Prehospital Fractures
Inhaled methoxyflurane successfully facilitated prehospital limb reduction in 54% of patients without requiring intravenous sedation.
Serum Neurofilament Light Chain Identifies Subclinical Axonal Injury in SMA Neonates
Elevated serum neurofilament light chain levels predict two-year motor outcomes and reveal active denervation before clinical symptoms appear.
CTA Plaque-RADS Predicts Ipsilateral Recurrence in Embolic Stroke
A standardized scoring system for nonstenotic carotid plaques identifies a distinct ESUS subgroup with a threefold higher risk of recurrence.
US Adult Obesity Projected to Reach 47 Percent by 2035
An analysis of over 11 million adults reveals severe racial and geographic disparities as obesity rates continue to climb nationwide.
Cognitive Status Remains Key Predictor of Dementia Risk Alongside p-tau181
ARIC data show that while p-tau181 is prognostic, the absolute risk of dementia remains low in cognitively unimpaired individuals.
Young Children Require Higher Benzodiazepine Doses for PICU Ventilation
A retrospective cohort study reveals that children under five receive significantly higher weight-adjusted doses of midazolam and lorazepam.