Intravenous Tocilizumab Stabilizes Severe Pediatric Neuroinflammation Within 72 Hours
A retrospective study shows rapid clinical improvement and intracranial pressure reduction in children with refractory CNS inflammation.
Intravenous NAD+ Reduces Post-Resuscitation Lung Injury in Swine Model
Exogenous NAD+ administration improves oxygenation and limits pulmonary edema by inhibiting ferroptosis-mediated cell death.
Spectral CT Reconstructions Improve Acute Bowel Ischemia Detection
Adding iodine maps and monoenergetic images to portal venous CT increases diagnostic accuracy from 73% to 86% across scanner platforms.
Mild Acute Kidney Injury Minimally Affects Long-Term Kidney Function Decline
A study of 1,603 patients finds that mild to moderate AKI causes a small permanent drop in GFR without accelerating annual decline.
Helicopter Transport Increases Survival for Specific High-Risk Trauma Phenotypes
Patients with low Glasgow Coma Scale scores and respiratory distress show the greatest benefit from air medical evacuation.
Targeted sFlt-1 Apheresis Safely Extends Pregnancy in Very Preterm Preeclampsia
A pilot trial shows selective removal of sFlt-1 reduces maternal blood pressure and delays delivery by a median of 10 days.
Absence of Chest Pain Predicts Severe Pediatric Myocarditis Risk
A retrospective study identifies hemodynamic instability and elevated procalcitonin as key markers for ICU admission in children.
Continuous Probabilities Identify High-Risk Patients in Hypoinflammatory Respiratory Failure
Continuous modeling of IL-6 and sTNFR-1 reveals a 40% mortality risk in patients masked by binary inflammatory classification.
Low MicroRNA-362 Linked to Acute Lung Injury After Murine Brain Trauma
Downregulation of microRNA-362-3' in extracellular vesicles fails to suppress proinflammatory TIMP-1 in a mouse model of head injury.
Non-Invasive Tools Estimate Intracranial Pressure When Invasive Monitoring Is Contraindicated
A review evaluates ultrasound and imaging techniques to detect intracranial hypertension in patients with coagulopathy or liver failure.
Videolaryngoscopy Increases First-Attempt Success for Double-Lumen Tube Intubation
A multicenter trial of 916 patients shows digital visualization improves glottic view and reduces esophageal intubation rates.
Serum Neurofilament Light Chain Tracks Acute Injury in Refractory Status Epilepticus
Elevated NfL levels distinguish cryptogenic NORSE from other seizure etiologies and correlate with poor functional outcomes at discharge.